Predicting mixture toxicity of seven phenolic compounds with similar and dissimilar action mechanisms to Vibrio qinghaiensis sp.nov.Q67

被引：30
作者：
Huang, Wei Ying [2 ]
Liu, Fei [2 ]
Liu, Shu Shen [1 ]
Ge, Hui Lin
Chen, Hong Han [2 ]
机构：
[1] Tongji Univ, Coll Environm Sci & Engn, Key Lab Yangtze River Water Environm, Minist Educ, Shanghai 200092, Peoples R China
[2] China Univ Geosci, Beijing Key Lab Water Resources & Environm Engn, Beijing 100083, Peoples R China
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2011年 / 74卷 / 06期
关键词：
Concentration addition; Independent action; Phenolic compounds; Toxicity; Weibull; JOINT ALGAL TOXICITY; MULTIPLE CHEMICAL-MIXTURES; INDEPENDENT ACTION; CONCENTRATION ADDITION; ESTROGENIC CHEMICALS; PESTICIDE MIXTURES; RISK ASSESSMENT; UNIFORM DESIGN; DAPHNIA-MAGNA; WATER;
D O I：
10.1016/j.ecoenv.2011.01.007
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The predictions of mixture toxicity for chemicals are commonly based on two models: concentration addition (CA) and independent action (IA). Whether the CA and IA can predict mixture toxicity of phenolic compounds with similar and dissimilar action mechanisms was studied. The mixture toxicity was predicted on the basis of the concentration-response data of individual compounds. Test mixtures at different concentration ratios and concentration levels were designed using two methods. The results showed that the Weibull function fit well with the concentration-response data of all the components and their mixtures, with all relative coefficients (Rs) greater than 0.99 and root mean squared errors (RMSEs) less than 0.04. The predicted values from CA and IA models conformed to observed values of the mixtures. Therefore, it can be concluded that both CA and IA can predict reliable results for the mixture toxicity of the phenolic compounds with similar and dissimilar action mechanisms. (C) 2011 Elsevier Inc. All rights reserved.
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收藏
页码：1600 / 1606
页数：7
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