The course of adrenomedullin and endothelin levels in patients with vasodilatory shock after cardiac surgery compared to patients after uncomplicated elective cardiac surgery

被引：5

作者：

Hillinger, Petra ^{[1
]}

Mayr, Viktoria D. ^{[2
]}

Luger, Markus ^{[1
]}

Tauber, Helmuth ^{[1
]}

Luckner, Guenter ^{[1
]}

Morgenthaler, Nils G. ^{[3
]}

Duenser, Martin ^{[4
,5
]}

Jochberger, Stefan ^{[1
]}

机构：

[1] Univ Hosp Innsbruck, Dept Anaesthesia & Intens Care Med, Anichstr 35, A-6020 Innsbruck, Austria

[2] Landesklin Hallein, Dept Anaesthesia, Hallein, Austria

[3] InV BioTech Serv GmbH, Hennigsdorf, Germany

[4] Kepler Univ Hosp, Dept Anaesthesia & Intens Care Med, Linz, Austria

[5] Johannes Kepler Univ Linz, Linz, Austria

来源：

JOURNAL OF CRITICAL CARE | 2022年 / 69卷

关键词：

Adrenomedullin; Endothelin; Vasodilatory shock; Cardiac surgery; PLASMA;

D O I：

10.1016/j.jcrc.2022.154009

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Purpose: The aim of this study was to analyse the course of adrenomedullin (ADM) and endothelin-1 (ET-1) levels in patients with vasodilatory shock after cardiac surgery and to explore differences compared to patients after uncomplicated coronary artery bypass graft (CABG) surgery. ADM and ET-1 are involved in the vasomotor response during vasodilatory shock. Materials and methods: We included 32 patients with vasodilatory shock (study group) and 10 patients after uncomplicated CABG surgery (control group). Daily measurements of MR-proADM and CT-proET-1 (stable surrogate markers for ADM and ET-1) were collected during the first 7 postoperative days. Results: MR-proADM and CT-proET-1 levels were significantly elevated in the study group when compared to the control group. In addition, the course of both biomarkers was significantly different in the study versus control group. Higher levels of both biomarkers were associated with organ dysfunction (higher maximum multiple organ dysfunction score, acute kidney injury). Conclusions: Significantly higher levels of MR-proADM and CT-proET-1 and a different course of both biomarkers were observed in patients with vasodilatory shock after cardiac surgery and seemed to be associated with organ dysfunction. (c) 2022 Elsevier Inc. All rights reserved.

引用

页数：7

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