Macrophage, a potential targeted therapeutic immune cell for cardiomyopathy

被引：11

作者：

Chen, Ganyi ^{[1
]}

Jiang, Hongwei ^{[1
]}

Yao, Yiwei ^{[1
]}

Tao, Zhonghao ^{[2
]}

Chen, Wen ^{[1
]}

Huang, Fuhua ^{[1
]}

Chen, Xin ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Thorac & Cardiovasc Surg, Nanjing, Jiangsu, Peoples R China

[2] Tongji Univ, Shanghai Pulm Hosp, Shanghai, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

基金：

中国国家自然科学基金;

关键词：

macrophage; heart failure; cardiomyopathy; phenotype; resident macrophages; RESIDENT CARDIAC MACROPHAGES; GLOBAL BURDEN; BONE-MARROW; FIBROBLAST; ACTIVATION; DIAGNOSIS; FIBROSIS; EPIDEMIOLOGY; INFLAMMATION; RECRUITMENT;

D O I：

10.3389/fcell.2022.908790

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cardiomyopathy is a major cause of heart failure, leading to systolic and diastolic dysfunction and promoting adverse cardiac remodeling. Macrophages, as key immune cells of the heart, play a crucial role in inflammation and fibrosis. Moreover, exogenous and cardiac resident macrophages are functionally and phenotypically different during cardiac injury. Although experimental evidence has shown that macrophage-targeted therapy is promising in cardiomyopathy, clinical translation remains challenging. In this article, the molecular mechanism of macrophages in cardiomyopathy has been discussed in detail based on existing literature. The issues and considerations of clinical treatment strategies for myocardial fibrosis has also been analyzed.

引用

页数：9

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