Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin

被引：241

作者：

Yan, Z ^{[1
]}

Hsieh-Wilson, L ^{[1
]}

Feng, JA ^{[1
]}

Tomizawa, K ^{[1
]}

Allen, PB ^{[1
]}

Fienberg, AA ^{[1
]}

Nairn, AC ^{[1
]}

Greengard, P ^{[1
]}

机构：

[1] Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA

来源：

NATURE NEUROSCIENCE | 1999年 / 2卷 / 01期

关键词：

D O I：

10.1038/4516

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.

引用

页码：13 / 17

页数：5

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