Antibody responses to envelope glycoproteins in HIV-1 infection

被引：327

作者：

Burton, Dennis R. ^{[1
,2
,3
,4
,5
]}

Mascola, John R. ^{[6
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Int AIDS Vaccine Initiat Neutralizing Antibody Ct, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA

[4] MIT, Massachusetts Gen Hosp, Ragon Inst, Boston, MA USA

[5] Harvard Univ, Boston, MA 02115 USA

[6] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 06期

关键词：

BROADLY NEUTRALIZING ANTIBODIES; DEPENDENT CELLULAR CYTOTOXICITY; MUCOSAL SHIV CHALLENGE; IMMUNODEFICIENCY-VIRUS; MONOCLONAL-ANTIBODIES; NONNEUTRALIZING ANTIBODIES; MEDIATED CYTOTOXICITY; PASSIVE TRANSFER; FC-RECEPTOR; ENV TRIMERS;

D O I：

10.1038/ni.3158

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibody responses to the HIV-1 envelope glycoproteins can be classified into three groups. Binding but non-neutralizing responses are directed to epitopes that are expressed on isolated envelope glycoproteins but not on the native envelope trimer found on the surface of virions and responsible for mediating the entry of virus into target cells. Strain-specific responses and broadly neutralizing responses, in contrast, target epitopes that are expressed on the native trimer, as revealed by recently resolved structures. The past few years have seen the isolation of many broadly neutralizing antibodies of remarkable potency that have shown prophylactic and therapeutic activities in animal models. These antibodies are helping to guide rational vaccine design and therapeutic strategies for HIV-1.

引用

页码：571 / 576

页数：6

共 108 条

[1] Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity [J].

Ackerman, Margaret E. ;

Crispin, Max ;

Yu, Xiaojie ;

Baruah, Kavitha ;

Boesch, Austin W. ;

Harvey, David J. ;

Dugast, Anne-Sophie ;

Heizen, Erin L. ;

Ercan, Altan ;

Choi, Ickwon ;

Streeck, Hendrik ;

Nigrovic, Peter A. ;

Bailey-Kellogg, Chris ;

Scanlan, Chris ;

Alter, Galit .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (05) :2183-2192

[2] RAPID DEVELOPMENT OF ISOLATE-SPECIFIC NEUTRALIZING ANTIBODIES AFTER PRIMARY HIV-1 INFECTION AND CONSEQUENT EMERGENCE OF VIRUS VARIANTS WHICH RESIST NEUTRALIZATION BY AUTOLOGOUS SERA [J].

ALBERT, J ;

ABRAHAMSSON, B ;

NAGY, K ;

AURELIUS, E ;

GAINES, H ;

NYSTROM, G ;

FENYO, EM .

AIDS, 1990, 4 (02) :107-112

[3] A Novel Assay for Antibody-Dependent Cell-Mediated Cytotoxicity against HIV-1-or SIV-Infected Cells Reveals Incomplete Overlap with Antibodies Measured by Neutralization and Binding Assays [J].

Alpert, Michael D. ;

Heyer, Lisa N. ;

Williams, David E. J. ;

Harvey, Jackson D. ;

Greenough, Thomas ;

Allhorn, Maria ;

Evans, David T. .

JOURNAL OF VIROLOGY, 2012, 86 (22) :12039-12052

[4] RECOMBINANT HUMAN FAB FRAGMENTS NEUTRALIZE HUMAN TYPE-1 IMMUNODEFICIENCY VIRUS INVITRO [J].

BARBAS, CF ;

BJORLING, E ;

CHIODI, F ;

DUNLOP, N ;

CABABA, D ;

JONES, TM ;

ZEBEDEE, SL ;

PERSSON, MAA ;

NARA, PL ;

NORRBY, E ;

BURTON, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9339-9343

[5] Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys [J].

Barouch, Dan H. ;

Whitney, James B. ;

Moldt, Brian ;

Klein, Florian ;

Oliveira, Thiago Y. ;

Liu, Jinyan ;

Stephenson, Kathryn E. ;

Chang, Hui-Wen ;

Shekhar, Karthik ;

Gupta, Sanjana ;

Nkolola, Joseph P. ;

Seaman, Michael S. ;

Smith, Kaitlin M. ;

Borducchi, Erica N. ;

Cabral, Crystal ;

Smith, Jeffrey Y. ;

Blackmore, Stephen ;

Sanisetty, Srisowmya ;

Perry, James R. ;

Beck, Matthew ;

Lewis, Mark G. ;

Rinaldi, William ;

Chakraborty, Arup K. ;

Poignard, Pascal ;

Nussenzweig, Michel C. ;

Burton, Dennis R. .

NATURE, 2013, 503 (7475) :224-+

[6]

Baum LL, 1996, J IMMUNOL, V157, P2168

[7] Comprehensive cross-clade neutralization analysis of a panel of anti-human immunodeficiency virus type 1 monoclonal antibodies [J].

Binley, JA ;

Wrin, T ;

Korber, B ;

Zwick, MB ;

Wang, M ;

Chappey, C ;

Stiegler, G ;

Kunert, R ;

Zolla-Pazner, S ;

Katinger, H ;

Petropoulos, CJ ;

Burton, DR .

JOURNAL OF VIROLOGY, 2004, 78 (23) :13232-13252

[8] Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C [J].

Binley, James M. ;

Lybarger, Elizabeth A. ;

Crooks, Emma T. ;

Seaman, Michael S. ;

Gray, Elin ;

Davis, Katie L. ;

Decker, Julie M. ;

Wycuff, Diane ;

Harris, Linda ;

Hawkins, Natalie ;

Wood, Blake ;

Nathe, Cory ;

Richman, Douglas ;

Tomaras, Georgia D. ;

Bibollet-Ruche, Frederic ;

Robinson, James E. ;

Morris, Lynn ;

Shaw, George M. ;

Montefiori, David C. ;

Mascola, John R. .

JOURNAL OF VIROLOGY, 2008, 82 (23) :11651-11668

[9] Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers [J].

Blattner, Claudia ;

Lee, Jeong Hyun ;

Sliepen, Kwinten ;

Derking, Ronald ;

Falkowska, Emilia ;

de la Pena, Alba Torrents ;

Cupo, Albert ;

Julien, Jean-Philippe ;

van Gils, Marit ;

Lee, Peter S. ;

Peng, Wenjie ;

Paulson, James C. ;

Poignard, Pascal ;

Burton, Dennis R. ;

Moore, John P. ;

Sanders, Rogier W. ;

Wilson, Ian A. ;

Ward, Andrew B. .

IMMUNITY, 2014, 40 (05) :669-680

[10] Role of donor genital tract HIV-1 diversity in the transmission bottleneck [J].

Boeras, Debrah I. ;

Hraber, Peter T. ;

Hurlston, Mackenzie ;

Evans-Strickfaden, Tammy ;

Bhattacharya, Tanmoy ;

Giorgi, Elena E. ;

Mulenga, Joseph ;

Karita, Etienne ;

Korber, Bette T. ;

Allen, Susan ;

Hart, Clyde E. ;

Derdeyn, Cynthia A. ;

Hunter, Eric .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (46) :E1156-E1163

← 1 2 3 4 5 6 7 8 9 10 →