Software-based risk stratification of pulmonary adenocarcinomas manifesting as pure ground glass nodules on computed tomography

被引:30
作者
Nemec, Ursula [1 ]
Heidinger, Benedikt H. [2 ]
Anderson, Kevin R. [3 ]
Westmore, Michael S. [4 ]
VanderLaan, Paul A. [3 ]
Bankier, Alexander A. [2 ]
机构
[1] Med Univ Vienna, Vienna Gen Hosp, Dept Biomed Imaging & Image Guided Therapy, Waehringer Guertel 18-20, Vienna, Austria
[2] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Radiol, Boston, MA USA
[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Pathol, Boston, MA USA
[4] Imbio, Delafield, WI USA
关键词
Lung adenocarcinoma; Pure ground glass nodule; Risk stratification; Computed tomography; Software based; LUNG ADENOCARCINOMA; CT; MANAGEMENT; OPACITIES; CLASSIFICATION; DIAGNOSIS; SPECTRUM; LESIONS; CANCER; MM;
D O I
10.1007/s00330-017-4937-2
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
To assess the performance of the "Computer-Aided Nodule Assessment and Risk Yield" (CANARY) software in the differentiation and risk assessment of histological subtypes of lung adenocarcinomas manifesting as pure ground glass nodules on computed tomography (CT). 64 surgically resected and histologically proven adenocarcinomas manifesting as pure ground-glass nodules on CT were assessed using CANARY software, which classifies voxel-densities into three risk components (low, intermediate, and high risk). Differences in risk components between histological adenocarcinoma subtypes were analysed. To determine the optimal threshold reflecting the presence of an invasive focus, sensitivity, specificity, negative predictive value, and positive predictive value were calculated. 28/64 (44%) were adenocarcinomas in situ (AIS); 26/64 (41%) were minimally invasive adenocarcinomas (MIA); and 10/64 (16%) were invasive ACs (IAC). The software showed significant differences in risk components between histological subtypes (P < 0.001-0.003). A relative volume of 45% or less of low-risk components was associated with histological invasiveness (specificity 100%, positive predictive value 100%). CANARY-based risk assessment of ACs manifesting as pure ground glass nodules on CT allows the differentiation of their histological subtypes. A threshold of 45% of low-risk components reflects invasiveness in these groups. aEuro cent CANARY-based risk assessment allows the differentiation of their histological subtypes. aEuro cent 45% or less of low-risk component reflects histological invasiveness. aEuro cent CANARY has potential role in suspected adenocarcinomas manifesting as pure ground-glass nodules.
引用
收藏
页码:235 / 242
页数:8
相关论文
共 22 条
  • [1] Anderson KR, 2017, AM J CLIN PATHOL, V147, P641, DOI [10.1093/AJCP/AQX036, 10.1093/ajcp/aqx036]
  • [2] Emphysema: Effect of reconstruction algorithm on CT imaging measures
    Boedeker, KL
    McNitt-Gray, MF
    Rogers, SR
    Truong, DA
    Brown, MS
    Gjertson, DW
    Goldin, JG
    [J]. RADIOLOGY, 2004, 232 (01) : 295 - 301
  • [3] Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy
    Cho, Jaeyoung
    Ko, Sung-Jun
    Kim, Se Joong
    Lee, Yeon Joo
    Park, Jong Sun
    Cho, Young-Jae
    Yoon, Ho Il
    Cho, Sukki
    Kim, Kwhanmien
    Jheon, Sanghoon
    Lee, Jae Ho
    Lee, Choon-Taek
    [J]. BMC CANCER, 2014, 14
  • [4] Screening for Lung Cancer Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    Detterbeck, Frank C.
    Mazzone, Peter J.
    Naidich, David P.
    Bach, Peter B.
    [J]. CHEST, 2013, 143 (05) : E78 - E92
  • [5] The Bronchioloalveolar carcinoma and peripheral adenocarcinoma spectrum of diseases
    Garfield, David H.
    Cadranel, Jacques L.
    Wislez, Marie
    Franklin, Wilbur A.
    Hirsch, Fred R.
    [J]. JOURNAL OF THORACIC ONCOLOGY, 2006, 1 (04) : 344 - 359
  • [6] Heidinger Benedikt H., 2017, SIZE MEASUREMENT T S
  • [7] Heidinger Benedikt H., 2017, J THORACIC ONCOLOGY
  • [8] Management of ground-glass opacities: should all pulmonary lesions with ground-glass opacity be surgically resected?
    Kobayashi, Yoshihisa
    Mitsudomi, Tetsuya
    [J]. TRANSLATIONAL LUNG CANCER RESEARCH, 2013, 2 (05) : 354 - 363
  • [9] New WHO classification of lung adenocarcinoma and preneoplasia
    Lantuejoul, Sylvie
    Rouquette, Isabelle
    Brannbilla, Elisabeth
    Travis, William D.
    [J]. ANNALES DE PATHOLOGIE, 2016, 36 (01) : 5 - 14
  • [10] Invasive Pulmonary Adenocarcinomas versus Preinvasive Lesions Appearing as Ground-Glass Nodules: Differentiation by Using CT Features
    Lee, Sang Min
    Park, Chang Min
    Goo, Jin Mo
    Lee, Hyun-Ju
    Wi, Jae Yeon
    Kang, Chang Hyun
    [J]. RADIOLOGY, 2013, 268 (01) : 265 - 273