Drug-Induced Liver Injury in GI Practice

被引：48

作者：

Sandhu, Naemat ^{[1
]}

Navarro, Victor ^{[1
]}

机构：

[1] Albert Einstein Healthcare Network, Div Digest Dis & Transplantat, 5501 Old York Rd,Klein 505, Philadelphia, PA 19141 USA

来源：

HEPATOLOGY COMMUNICATIONS | 2020年 / 4卷 / 05期

基金：

美国国家卫生研究院;

关键词：

DIETARY-SUPPLEMENT USE; CLINICAL-FEATURES; CAUSALITY ASSESSMENT; FATTY LIVER; ADVERSE REACTIONS; ORAL MEDICATIONS; US ADULTS; OUTCOMES; FAILURE; HEPATOTOXICITY;

D O I：

10.1002/hep4.1503

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Although drug-induced liver injury (DILI) is a rare clinical event, it carries significant morbidity and mortality, leaving it as the leading cause of acute liver failure in the United States. It is one of the most challenging diagnoses encountered by gastroenterologists. The development of various drug injury networks has played a vital role in expanding our knowledge regarding drug-related and herbal and dietary supplement-related liver injury. In this review, we discuss what defines liver injury, epidemiology of DILI, its biochemical and pathologic patterns, and management.

引用

收藏

页码：631 / 645

页数：15

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