Silylation-Based Kinetic Resolution of Monofunctional Secondary Alcohols

被引：68

作者：

Sheppard, Cody I. ^{[1
]}

Taylor, Jessica L. ^{[1
]}

Wiskur, Sheryl L. ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 15期

基金：

美国国家科学基金会;

关键词：

ENANTIOSELECTIVE ACYLATION; STEREOSELECTIVE SILYLATION; CATALYST; HYDROGENATION; ROTATION; CRYSTAL; SILANES;

D O I：

10.1021/ol2012617

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nucleophilic small molecule catalyst (-)-tetramisole was found to catalyze the kinetic resolution of monofunctional secondary alcohols via enantioselective silylation. Optimization of this new methodology allows for selectivity factors up to 25 utilizing commercially available reagents and mild reaction conditions.

引用

页码：3794 / 3797

页数：4

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