Novel β-cyclodextrin chiral stationary phases with different length spacers for normal-phase high performance liquid chromatography enantioseparation

被引：58

作者：

Lai, Xianghua ^{[2
]}

Tang, Weihua ^{[1
]}

Ng, Siu-Choon ^{[2
]}

机构：

[1] Nanjing Univ Sci & Technol, Minist Educ, Key Lab Soft Chem & Funct Mat, Nanjing 210094, Peoples R China

[2] Nanyang Technol Univ, Coll Engn, Div Chem & Biomol Engn, Singapore 637722, Singapore

来源：

JOURNAL OF CHROMATOGRAPHY A | 2011年 / 1218卷 / 22期

关键词：

Chiral stationary phase; Cyclodextrin; Spacer; Enantioseparation; SILICA-GEL; FACILE SYNTHESIS; SEPARATIONS; IMMOBILIZATION; RECOGNITION; RESOLUTION; HPLC;

D O I：

10.1016/j.chroma.2011.03.071

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclodextrin and its derivatives are widely used as selectors of chiral stationary phases (CSPs) for high performance liquid chromatography (HPLC) due to their unique molecular structure and resolution capability. Three mono(6(A)-N-(omega-alkenylamino)-6(A)-deoxy)perphenylcarbamoylated beta-cyclodextrin (PICD) based CSPs with different length spacers have been prepared, with their enantioseparation abilities evaluated with 10 model racemates including aromatic alcohols, flavanone compounds, amine and non-protolytic compounds under normal-phase conditions. The effect of spacer length and surface loading on the enantioseparation performance of CSPs is investigated herewith. The results indicate that higher surface loading 6C-PICD displays the best enantioselectivities towards selected racemates under normal-phase conditions. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：3496 / 3501

页数：6

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