Advances of signal transduction of reactive oxygen species

Signal transduction of reactive oxygen species (ROS) has been of great interest recent years. ROS may signal through oxidation or reducton of specific groups such as cystein residues or redox-active iron center on certain biomolecules, or through modulating cellular redox status in different cell types. There were many documents indicating that signal pathway of ROS associate with some well-known regulating molecules as following: protein tyrosine kinase (PTK), protein kinase C (PKC), mitogen activated protein kinase (MAPK), nuclear factor NF-kappaB, AP-1 and Ca2+, cGMP. Although great advances of signal transduction of reactive oxygen species has been taken in recent years, there are many important questions remained to be answer in future.