Biochemical study on modifying role of variants of leptin gene and its receptor on serum leptin levels in breast cancer

被引：5

作者：

Tayel, Safaa, I ^{[1
]}

Alhanafy, Alshimaa M. ^{[2
]}

Ahmed, Solwan M. ^{[3
]}

Eltorgoman, Abdelmoneim A. ^{[4
]}

Elsayed, Ibrahim E. ^{[5
]}

机构：

[1] Menoufia Univ, Fac Med, Med Biochem & Mol Biol Dept, Menoufia, Egypt

[2] Menoufia Univ, Fac Med, Clin Oncol & Nucl Med Dept, Menoufia, Egypt

[3] Menoufia Univ, Fac Sci, Menoufia, Egypt

[4] Menoufia Univ, Fac Sci, Organ Chem Dept, Menoufia, Egypt

[5] Menoufia Univ, Fac Sci, Organ & Med Chem Dept, Menoufia, Egypt

来源：

MOLECULAR BIOLOGY REPORTS | 2020年 / 47卷 / 05期

关键词：

Breast cancer; HER2; Leptin; Leptin receptor polymorphism; OB GENE; RISK; POLYMORPHISMS; ASSOCIATION; OBESITY; ADIPONECTIN; CELLS;

D O I：

10.1007/s11033-020-05436-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The leptin is discharged from breast adipose tissue and is overexpressed in breast cancer (BC). Conflicting relation of leptin with BC was reported. We investigated this association and its impact on leptin level and disease characteristics. The study included 70 females (40 women with pathological proof of invasive BC patients and 30 controls). LEP and LEPR polymorphisms were evaluated by real-time PCR. Serum leptin was estimated by ELISA. Both LEPR and LEP disturbances increase the danger of BC where GG genotype and G allele frequencies of LEPR were higher in patients vs. control. GG genotype increases BC risk with OR (9.1) while G allele predisposes to disease with OR (3.8). Furthermore, LEP A allele was uniquely elevated in patients than healthy ones with OR (2.06). Precise relation of circulating leptin and its polymorphisms with predicting BC may authorize its utilization in early screening.

引用

页码：3807 / 3820

页数：14

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