Gold-catalyzed cascade C-H/C-H cross-coupling/cyclization/alkynylation: an efficient access to 3-alkynylpyrroles

被引：22
作者：
Zhang, Shuai
Ma, Yuanhong
Lan, Jingbo
Song, Feijie [1 ]
You, Jingsong
机构：
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 21期
关键词：
TERMINAL ALKYNES; DIRECT ALKYNYLATION; ORGANOGOLD COMPOUNDS; ENAMINO ESTERS; BOND FORMATION; PYRROLES; ACTIVATION; HETEROCYCLES; DERIVATIVES; CYCLIZATION;
D O I：
10.1039/c5ob00599j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient approach to 3-alkynylpyrroles has been developed through the gold-catalyzed reaction of beta-enamino derivatives with terminal alkynes, which features complete regiocontrol, relatively wide substrate scope, and high functional group tolerance. Mechanistic studies show that the reaction proceeds through the gold-catalyzed cascade oxidative C-H/C-H cross-coupling, cyclization and alkynylation.
引用
收藏
页码：5867 / 5870
页数：4
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