Molecular genetic analysis of haematological malignancies: I. Acute leukaemias and myeloproliferative disorders

被引：9
作者：
Bench, AJ [1 ]
Erber, WN [1 ]
Scott, MA [1 ]
机构：
[1] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Haematooncol Diagnost Serv, Dept Haematol, Cambridge CB2 2QQ, England
来源：
CLINICAL AND LABORATORY HAEMATOLOGY | 2005年 / 27卷 / 03期
关键词：
molecular analysis; acute leukaemia; chronic myeloproliferative disorders; minimal residual disease; polymerase chain reaction;
D O I：
10.1111/j.1365-2257.2005.00701.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Molecular genetic techniques are now routinely applied to haematological malignancies within a clinical laboratory setting. The detection of genetic rearrangements not only assists with diagnosis and treatment decisions, but also adds important prognostic information. In addition, genetic rearrangements associated with leukaemia can be used as molecular markers allowing the detection of low levels of residual disease. This review will concentrate on the application of molecular genetic techniques to the acute leukaemias and myeloprolferative disorders.
引用
收藏
页码：148 / 171
页数：24
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