Forces Driving Epithelial Spreading in Zebrafish Gastrulation

被引：312

作者：

Behrndt, Martin ^{[2
,3
]}

Salbreux, Guillaume ^{[1
]}

Campinho, Pedro ^{[3
]}

Hauschild, Robert ^{[3
]}

Oswald, Felix ^{[2
]}

Roensch, Julia ^{[3
]}

Grill, Stephan W. ^{[1
,2
]}

Heisenberg, Carl-Philipp ^{[3
]}

机构：

[1] Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany

[2] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[3] IST Austria, A-3400 Klosterneuburg, Austria

来源：

SCIENCE | 2012年 / 338卷 / 6104期

基金：

奥地利科学基金会;

关键词：

MORPHOGENESIS; DROSOPHILA; MOVEMENT;

D O I：

10.1126/science.1224143

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Contractile actomyosin rings drive various fundamental morphogenetic processes ranging from cytokinesis to wound healing. Actomyosin rings are generally thought to function by circumferential contraction. Here, we show that the spreading of the enveloping cell layer (EVL) over the yolk cell during zebrafish gastrulation is driven by a contractile actomyosin ring. In contrast to previous suggestions, we find that this ring functions not only by circumferential contraction but also by a flow-friction mechanism. This generates a pulling force through resistance against retrograde actomyosin flow. EVL spreading proceeds normally in situations where circumferential contraction is unproductive, indicating that the flow-friction mechanism is sufficient. Thus, actomyosin rings can function in epithelial morphogenesis through a combination of cable-constriction and flow-friction mechanisms.

引用

页码：257 / 260

页数：4

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