Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphoma

被引：22

作者：

Howe, D ^{[1
]}

Bromidge, T ^{[1
]}

机构：

[1] Musgrove Pk Hosp, Leukaemia Res Lab, Taunton & Somerset NHS Trust, Taunton TA1 5DA, Somerset, England

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 01期

关键词：

LEF-1; CLL; low-grade NHL;

D O I：

10.1016/j.leukres.2005.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During normal B-lymphocyte development once cells pass the pro-B stage the transcription factor LEF-1, a key component of the Wnt/beta-catenin pathway, is down regulated. However studies have shown that B-cell chronic lymphocytic leukaemia (CLL) lymphocytes, which have a mature B-cell phenotype, still express abundant LEF-1. This study demonstrates that although LEF-1 mRNA is universally, highly expressed in B-CLL, expression of this gene is much lower or absent in the majority of low-grade B-cell non-Hodgkin's lymphoma (NHL). This suggests that there exist key differences in the activity of the Wnt/beta-catenin pathway between low-grade B-cell malignancies. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：29 / 32

页数：4

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