Inhibition by insulin of hypothalamic VMN neurons in rats overweight due to postnatal overfeeding

被引：47
作者：
Davidowa, H
Plagemann, A
机构：
[1] Humboldt Univ, Fac Med Charite, Johannes Mueller Inst Physiol, D-10117 Berlin, Germany
[2] Humboldt Univ, Fac Med Charite, Inst Expt Endocrinol, D-10098 Berlin, Germany
来源：
NEUROREPORT | 2001年 / 12卷 / 15期
关键词：
brain slice; insulin; overweight; postnatal overnutrition; rat hypothalamus; single unit activity;
D O I：
10.1097/00001756-200110290-00012
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Single unit activity was studied in brain slices of normal and overweight adolescent rats, the latter grown up until weaning in small litters of three pups per mother (SL). Significantly fewer neurons of the ventromedial hypothalamic nucleus (VMN) were activated by insulin in overweight SL rats than in normal (NL) rats (chi (2) p < 0.01). Although there is no significant difference between NL and SL rats in the number of VMN neurons responsive to insulin, the neurons differ in the type of reaction. In overweight SL rats neurons were mainly inhibited by insulin (Wilcoxon test p<0.0001, n=45). This altered response to the satiety signal insulin in postnatally over-nourished rats might contribute to their persisting hyperphagia and overweight. NeuroReport 12:3201-3204 (C) 2001 Lippincott Williams & Wilkins.
引用
收藏
页码：3201 / 3204
页数：4
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