A pan-cancer analysis of the oncogenic role of dual-specificity tyrosine (Y)-phosphorylation- regulated kinase 2 (DYRK2) in human tumors

被引：4
作者：
Qiu, Xinyue [1 ]
Shen, Cheng [4 ]
Zhao, Wenjing [1 ]
Zhang, Xunlei [2 ]
Zhao, Dakun [1 ]
Wu, Xuming [3 ]
Yang, Lei [2 ]
机构：
[1] Nantong Univ, Canc Res Ctr Nantong, Affiliated Tumor Hosp, 30 Tongyang North Rd, Nantong 226361, Peoples R China
[2] Nantong Univ, Dept Oncol, Affiliated Tumor Hosp, 30 Tongyang North Rd, Nantong 226361, Peoples R China
[3] Nantong Univ, Affiliated Mental Hlth Ctr, 37 Chenggang Rd, Nantong 226005, Peoples R China
[4] NewYork Univ, Tandon Sch Engn, Dept Comp Sci & Engn, Brooklyn, NY 11201 USA
来源：
SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期
关键词：
DNA METHYLATION; AMPLIFICATION; EXPRESSION; GENE; CELL; P53;
D O I：
10.1038/s41598-022-19087-7
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Although there have been studies correlating DYRK2 with a number of human cancers, there has been no pan-cancer analysis. Therefore, through the TCGA database, we conducted a related study on the expression of DYRK2 in cancers.The expression of DYRK2 is obviously increased in some cancers, while the opposite is true in others, and there is a clear association between its expression and the prognosis of cancer patients.The mutation of DYRK2 is also significantly correlated with patients' prognosis in certain human tumors. In addition, phosphorylation and methylation levels of DYRK2 are different between tumor tissues and adjacent normal tissues in various tumors. In the tumour microenvironment, the expression of DYRK2 correlates with cancer-associated fibroblast infiltration, such as BLCA or HNSC. In order to fully understand the role of DYRK2 in different tumors, we conducted a pan-cancer analysis.
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页数：11
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