Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro)

被引：17

作者：

Al-Garawi, Zahraa Salim M. ^{[1
]}

Tomi, Ivan Hameed R. ^{[1
]}

Al-Daraji, Ali Hussein R. ^{[1
]}

机构：

[1] Univ Al Mustansiriya, Coll Sci, Dept Chem, Baghdad, Iraq

来源：

E-JOURNAL OF CHEMISTRY | 2012年 / 9卷 / 02期

关键词：

COMPLEXES; CU(II); CO(II); NI(II);

D O I：

10.1155/2012/218675

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzaldehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and H-1 NMR spectroscopy. Their effects on the activity of total (ACP), prostatic (PAP) and non prostatic (NPA) acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A) demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B) demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5x10(-2), 5.5x10(-3) and 5.5x10(-4) M) and activator effect at low concentration (5.5x10(-5) M) while it was exhibits as activator on PAP activity.

引用

页码：962 / 969

页数：8

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