Fatal Disseminated Cryptococcus gattii Infection in New Mexico

被引:32
|
作者
Walraven, Carla J. [1 ,2 ]
Gerstein, Wendy [1 ,2 ]
Hardison, Sarah E. [3 ]
Wormley, Floyd [3 ]
Lockhart, Shawn R. [4 ]
Harris, Julie R. [4 ]
Fothergill, Annette [5 ]
Wickes, Brian [5 ]
Gober-Wilcox, Julie [1 ]
Massie, Larry [1 ]
Ku, T. S. Neil [1 ,2 ]
Firacative, Carolina [6 ]
Meyer, Wieland [6 ]
Lee, Samuel A. [1 ,2 ]
机构
[1] New Mexico Vet Healthcare Syst, Infect Dis Sect, Albuquerque, NM USA
[2] Univ New Mexico, Div Infect Dis, Hlth Sci Ctr, Albuquerque, NM 87131 USA
[3] Univ Texas San Antonio, Dept Biol, S Texas Ctr Emerging Infect Dis, San Antonio, TX USA
[4] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA USA
[5] Univ Texas Hlth Sci Ctr, Dept Microbiol & Immunol, San Antonio, TX USA
[6] Univ Sydney, Westmead Millennium Inst, Mol Mycol Res Lab, Ctr Infect Dis & Microbiol,Sydney Med Sch,Westmea, Sydney, NSW 2006, Australia
来源
PLOS ONE | 2011年 / 6卷 / 12期
关键词
NEOFORMANS VAR GATTII; CLASSICAL MACROPHAGE ACTIVATION; PACIFIC-NORTHWEST; BRITISH-COLUMBIA; VANCOUVER-ISLAND; OUTBREAK; CANADA; MENINGITIS; PARASITISM; GENOTYPE;
D O I
10.1371/journal.pone.0028625
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.
引用
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页数:8
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