TNNI3K in cardiovascular disease and prospects for therapy

被引：15
作者：
Milano, Annalisa [1 ]
Lodder, Elisabeth M. [1 ]
Bezzina, Connie R. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Clin & Expt Cardiol, NL-1105 AZ Amsterdam, Netherlands
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 82卷
关键词：
Tnni3k; Heart failure; Ischemia/reperfusion; Arrhythmia; Kinase; KINASE; LOCI; REVEALS; CLONING; MICE; OVEREXPRESSION; CARDIOMYOPATHY; SUSCEPTIBILITY; MECHANISMS; EXPRESSION;
D O I：
10.1016/j.yjmcc.2015.03.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular diseases are an important cause of morbidity and mortality worldwide and the global burden of these diseases continues to grow. Therefore new therapies are urgently needed. The role of protein kinases in disease, including cardiac disease, is long recognized, making kinases important therapeutic targets. We here review the knowledge gathered in the last decade about troponin I-interacting kinase (TNNI3K), a kinase with cardiac-restricted expression that has been implicated in various cardiac phenotypes and diseases including heart failure, cardiomyopathy, ischemia/reperfusion injury and conduction of the cardiac electrical impulse. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：167 / 173
页数：7
相关论文
共 47 条
  • [1] Inhibition of the Cardiomyocyte-Specific Troponin I-Interacting Kinase Limits Oxidative Stress, Injury, and Adverse Remodeling due to Ischemic Heart Disease
    Abraham, Dennis M.
    Marchuk, Douglas A.
    [J]. CIRCULATION RESEARCH, 2014, 114 (06) : 938 - 940
  • [2] Complex genetic control of host susceptibility to coxsackievirus B3-induced myocarditis
    Aly, M.
    Wiltshire, S.
    Chahrour, G.
    Osti, J-C Loredo
    Vidal, S. M.
    [J]. GENES AND IMMUNITY, 2007, 8 (03) : 193 - 204
  • [3] Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity
    Anastassiadis, Theonie
    Deacon, Sean W.
    Devarajan, Karthik
    Ma, Haiching
    Peterson, Jeffrey R.
    [J]. NATURE BIOTECHNOLOGY, 2011, 29 (11) : 1039 - U117
  • [4] Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease
    Anderson, Mark E.
    Higgins, Linda S.
    Schulman, Howard
    [J]. NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE, 2006, 3 (08): : 437 - 445
  • [5] Comparative Phenotypic Assessment of Cardiac Pathology, Physiology, and Gene Expression in C3H/HeJ, C57BL/6J, and B6C3F1/J Mice
    Auerbach, Scott S.
    Thomas, Reuben
    Shah, Ruchir
    Xu, Hong
    Vallant, Molly K.
    Nyska, Abraham
    Dunnick, June K.
    [J]. TOXICOLOGIC PATHOLOGY, 2010, 38 (06) : 923 - 942
  • [6] Bezzina C, 1999, CIRC RES, V85, P1206
  • [7] Immunohistochemical approach to the pathogenesis of clinical cases of Bovine Herpesvirus type 5 infections
    Cardoso, Tereza C.
    Ferrari, Heitor F.
    Garcia, Andrea F.
    Bregano, Livia C.
    Andrade, Alexandre L.
    Nogueira, Adriana H. C.
    [J]. DIAGNOSTIC PATHOLOGY, 2010, 5 : 57
  • [8] Defective β-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression
    Cho, MC
    Rapacciuolo, A
    Koch, WJ
    Kobayashi, Y
    Jones, LR
    Rockman, HA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) : 22251 - 22256
  • [9] Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy
    Colak, Dilek
    Kaya, Namik
    Al-Zahrani, Jawaher
    Al Bakheet, Albandary
    Muiya, Paul
    Andres, Editha
    Quackenbush, John
    Dzimiri, Nduna
    [J]. GENOMICS, 2009, 94 (01) : 20 - 31
  • [10] Current status and new features of the Consensus Coding Sequence database
    Farrell, Catherine M.
    O'Leary, Nuala A.
    Harte, Rachel A.
    Loveland, Jane E.
    Wilming, Laurens G.
    Wallin, Craig
    Diekhans, Mark
    Barrell, Daniel
    Searle, Stephen M. J.
    Aken, Bronwen
    Hiatt, Susan M.
    Frankish, Adam
    Suner, Marie-Marthe
    Rajput, Bhanu
    Steward, Charles A.
    Brown, Garth R.
    Bennett, Ruth
    Murphy, Michael
    Wu, Wendy
    Kay, Mike P.
    Hart, Jennifer
    Rajan, Jeena
    Weber, Janet
    Snow, Catherine
    Riddick, Lillian D.
    Hunt, Toby
    Webb, David
    Thomas, Mark
    Tamez, Pamela
    Rangwala, Sanjida H.
    McGarvey, Kelly M.
    Pujar, Shashikant
    Shkeda, Andrei
    Mudge, Jonathan M.
    Gonzalez, Jose M.
    Gilbert, James G. R.
    Trevanion, Stephen J.
    Baertsch, Robert
    Harrow, Jennifer L.
    Hubbard, Tim
    Ostell, James M.
    Haussler, David
    Pruitt, Kim D.
    [J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) : D865 - D872
12345