Base excision DNA repair

被引:223
作者
Zharkov, D. O. [1 ]
机构
[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Div, Novosibirsk 630090, Russia
关键词
DNA damage; DNA repair; DNA glycosylase; AP endonuclease; DNA polymerase; DNA ligase;
D O I
10.1007/s00018-008-7543-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA repair is a collection of several multienzyme, multistep processes keeping the cellular genome intact against genotoxic insults. One of these processes is base excision repair, which deals with the most ubiquitous lesions in DNA: oxidative base damage, alkylation, deamination, sites of base loss and single-strand breaks, etc. Individual enzymes acting in base excision repair have been identified. The recent years were marked with many advances in understanding of their structure and many interactions that make base excision repair a functional, versatile system. This review describes the current knowledge of structural biology and biochemistry of individual steps of base excision repair, several subpathways of the common base excision repair pathway, and interactions of the repair process with other cellular processes.
引用
收藏
页码:1544 / 1565
页数:22
相关论文
共 275 条
[41]   Interaction of checkpoint proteins Hus1/Rad1/Rad9 with DNA base excision repair enzyme MutY homolog in fission yeast, Schizosaccharomyces pombe [J].
Chang, DY ;
Lu, AL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (01) :408-417
[42]   Increased sensitivity to sparsely ionizing radiation due to excessive base excision in clustered DNA damage sites in Escherichia coli [J].
Chang, PW ;
Zhang, QM ;
Takatori, K ;
Tachibana, A ;
Yonei, S .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 2005, 81 (02) :115-123
[43]   Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair [J].
Chapados, BR ;
Hosfield, DJ ;
Han, S ;
Qiu, JZ ;
Yelent, B ;
Shen, BH ;
Tainer, JA .
CELL, 2004, 116 (01) :39-50
[44]   Vpr-mediated incorporation of UNG2 into HIV-1 particles is required to modulate the virus mutation rate and for replication in macrophages [J].
Chen, RX ;
Le Rouzic, E ;
Kearney, JA ;
Mansky, LM ;
Benichou, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (27) :28419-28425
[45]   Roles of uracil-DNA glycosylase and dUTPase in virus replication [J].
Chen, RX ;
Wang, HT ;
Mansky, LM .
JOURNAL OF GENERAL VIROLOGY, 2002, 83 :2339-2345
[46]   An invariant aspartic acid in the DNA glycosylase domain of DEMETER is necessary for transcriptional activation of the imprinted MEDEA gene [J].
Choi, Y ;
Harada, JJ ;
Goldberg, RB ;
Fischer, RL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (19) :7481-7486
[47]   DEMETER, a DNA glycosylase domain protein, is required for endosperm gene imprinting and seed viability in Arabidopsis [J].
Choi, YH ;
Gehring, M ;
Johnson, L ;
Hannon, M ;
Harada, JJ ;
Goldberg, RB ;
Jacobsen, SE ;
Fischer, RL .
CELL, 2002, 110 (01) :33-42
[48]   A novel uracil-DNA glycosylase family related to the helix-hairpin-helix DNA glycosylase superfamily [J].
Chung, JH ;
Im, EK ;
Park, HY ;
Kwon, JH ;
Lee, S ;
Oh, J ;
Hwang, KC ;
Lee, JH ;
Jang, Y .
NUCLEIC ACIDS RESEARCH, 2003, 31 (08) :2045-2055
[49]   AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate [J].
Cistulli, C ;
Lavrik, OI ;
Prasad, R ;
Hou, E ;
Wilson, SH .
DNA REPAIR, 2004, 3 (06) :581-591
[50]   The enigmatic thymine DNA glycosylase [J].
Cortazar, Daniel ;
Kunz, Christophe ;
Saito, Yusuke ;
Steinacher, Roland ;
Schaer, Primo .
DNA REPAIR, 2007, 6 (04) :489-504