Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC

被引：4

作者：

Degim, T ^{[1
]}

Akay, C ^{[1
]}

Büyükafsar, K ^{[1
]}

Cevheroglu, S ^{[1
]}

机构：

[1] Army Drug Factory, Dept Qual Control, Ankara, Turkey

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2001年 / 26卷 / 01期

关键词：

simultaneous determination; codeine; ethyl morphine hydrochloride; tablet formulations; liquid chromatography;

D O I：

10.1016/S0731-7085(01)00392-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A reverse phase high performance liquid chromatography (HPLC) method was developed for the simultaneous determination or codeine (methyl morphine) and dionin (ethyl morphine hydrochloride) in antitussive analgesic tablet formulations. A C-18 column and methanol-water (1:2) mixture mobile phase (pH 3.0) were used. Spectrophotometric detection was carried out at 210 nm. The total elution time was shorter than 7 min. This method was found to be quite precise and reproducible. This proposed method was successfully applied to the determination of codeine and ethyl morphine hydrochloride in tablets produced by the Turkish Army Drug Factory. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：15 / 21

页数：7

共 4 条

[1]

BERGISADI N, 1987, ACTA PHARM TURC, V29, P81

[2] INFLUENCE OF HYDROLYSIS PROCEDURES ON THE URINARY CONCENTRATIONS OF CODEINE AND MORPHINE IN RELATION TO DOPING ANALYSIS [J].