The EUTOS population-based registry: incidence and clinical characteristics of 2904 CML patients in 20 European Countries

被引：179

作者：

Hoffmann, V. S. ^{[1
]}

Baccarani, M. ^{[2
]}

Hasford, J. ^{[1
]}

Lindoerfer, D. ^{[1
]}

Burgstaller, S. ^{[3
]}

Sertic, D. ^{[4
]}

Costeas, P. ^{[5
]}

Mayer, J. ^{[6
]}

Indrak, K. ^{[7
]}

Everaus, H. ^{[8
]}

Koskenvesa, P. ^{[9
,10
]}

Guilhot, J. ^{[11
]}

Schubert-Fritschle, G. ^{[12
]}

Castagnetti, F. ^{[13
]}

Di Raimondo, F. ^{[14
]}

Lejniece, S. ^{[15
]}

Griskevicius, L. ^{[16
]}

Thielen, N. ^{[17
]}

Sacha, T. ^{[18
]}

Hellmann, A. ^{[19
]}

Turkina, A. G. ^{[20
]}

Zaritskey, A. ^{[21
]}

Bogdanovic, A. ^{[22
]}

Sninska, Z. ^{[23
]}

Zupan, I. ^{[24
]}

Steegmann, J-L ^{[25
]}

Simonsson, B. ^{[26
]}

Clark, R. E. ^{[27
]}

Covelli, A. ^{[28
]}

Guidi, G. ^{[28
]}

Hehlmann, R. ^{[29
]}

机构：

[1] Univ Munich, Inst Med Informat Sci Biometry & Epidemiol, D-81377 Munich, Germany

[2] Univ Bologna, Dept Hematol & Oncol L & A, Bologna, Italy

[3] Klinikum Wells Grieskirchen, Dept Internal Med Haematol & Oncol 4, Wells, Austria

[4] Univ Hosp Ctr, Div Hematol, Dept Med, Zagreb, Croatia

[5] Karaiskakio Fdn, Nicosia, Cyprus

[6] Masaryk Univ Hosp, Dept Internal Med Hematooncol, Brno, Czech Republic

[7] Palacky Univ, Univ Hosp, Dept Hematol Oncol, CR-77147 Olomouc, Czech Republic

[8] Tartu Univ Hosp, Dept Hematol & Bone Marrow Transplantat, Tartu, Estonia

[9] Helsinki Univ Cent Hosp, Hematol Res Unit, Helsinki, Finland

[10] Biomedicum, Hematol Res Unit, Helsinki, Finland

[11] CHU, INSERM CIC 1402, Poitiers, France

[12] Univ Munich, Munich Canc Registry, D-81377 Munich, Germany

[13] Univ Bologna, Dept Specialist Diagnost & Expt Med, Bologna, Italy

[14] Univ Catania, Azienda Policlin OVE, Div Hematol, Catania, Italy

[15] Riga Eastern Clin Univ Hosp, Natl Hematol Ctr, Riga, Latvia

[16] Vilnius Univ Hosp, Santariskiu Klin, Vilnius, Lithuania

[17] Vrije Univ Amsterdam Med Ctr, Dept Hematol, Amsterdam, Netherlands

[18] Jagellonian Univ Hosp, Dept Hematol, Krakow, Poland

[19] Med Univ Gdansk, Dept Hematol & Transplantat, Gdansk, Poland

[20] Minist Russian Federat, FSBI Hematol Res Ctr Healthcare, Moscow, Russia

[21] St Petersburg State Med Univ, Inst Hematol, St Petersburg, Russia

[22] Univ Belgrade, Clin Ctr Serbia, Inst Haematol, Belgrade, Serbia

[23] Univ Hosp, Dept Hematol, Bratislava, Slovakia

[24] Univ Clin Ctr, Dept Hematol, Ljubljana, Slovenia

[25] Hosp Princesa, Hematol & Res Inst, Madrid, Spain

[26] Uppsala Univ, Dept Internal Med, Uppsala, Sweden

[27] Royal Liverpool Univ Hosp, Inst Translat Med, Liverpool, Merseyside, England

[28] Novartis Oncol Europe, Origgio, Italy

[29] Heidelberg Univ, Med Klin 3, Mannheim, Germany

来源：

LEUKEMIA | 2015年 / 29卷 / 06期

关键词：

CHRONIC MYELOID-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; HEMATOLOGIC MALIGNANCIES; IMATINIB TREATMENT; PROGNOSTIC SCORE; INTERFERON; FRONTLINE; SURVIVAL; AGE; RESPONSES;

D O I：

10.1038/leu.2015.73

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This population-based registry was designed to provide robust and updated information on the characteristics and the epidemiology of chronic myeloid leukemia (CML). All cases of newly diagnosed Philadelphia positive, BCR-ABL1+ CML that occurred in a sample of 92.5 million adults living in 20 European countries, were registered over a median period of 39 months. 94.3% of the 2904 CML patients were diagnosed in chronic phase (CP). Median age was 56 years. 55.5% of patients had comorbidities, mainly cardiovascular (41.9%). High-risk patients were 24.7% by Sokal, 10.8% by EURO, and 11.8% by EUTOS risk scores. The raw incidence increased with age from 0.39/100 000/year in people 20-29 years old to 1.52 in those >70 years old, and showed a maximum of 1.39 in Italy and a minimum of 0.69 in Poland (all countries together: 0.99). The proportion of Sokal and Euro score high-risk patients seen in many countries indicates that trial patients were not a positive selection. Thus from a clinical point of view the results of most trials can be generalized to most countries. The incidences observed among European countries did not differ substantially. The estimated number of new CML cases per year in Europe is about 6370.

引用

页码：1336 / 1343

页数：8

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