Four new steroidal components from Smilacina henryi and their cytotoxic activities

被引：3

作者：

Qiao, Fan ^{[1
]}

Yang, Jie ^{[2
]}

Lin, Jie ^{[2
]}

Yao, Sheng ^{[1
]}

机构：

[1] Weinan Cent Hosp, Shengli Rd, Weinan 714000, Peoples R China

[2] Shaanxi Univ Chinese Med, Western Century Ave, Xianyang 712046, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2019年 / 29卷

关键词：

Smilacina henryi; Steroidal components; Structure determination; Cytotoxicity; OLEANANE-TYPE SAPONINS; RHIZOMES; GLYCOSIDES; ROOTS;

D O I：

10.1016/j.phytol.2018.12.005

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new steroidal components (1-4) along with two known analogues (5-6) were obtained from the roots and rhizomes of Smilacina henryi. The components' structures were determined as (25S)-5 alpha-spirost-9(11)-ene-3 beta, 17 alpha, 21-triol (1), (24S, 25S)-5 alpha-spirost-9(11)-ene-3 beta, 17 alpha, 24-triol (2), (25S)-5 alpha-spirost-9(11)-ene-3 beta, 17 alpha-di-hydroxy-12-one (3), 5 alpha-cholest-9(11)-ene-3 beta, 26-dihydroxy-16, 22-dione (4), (25S)-5 alpha-spirostan-9(11)-en-3 beta, 17 alpha-diol (5), (25S)-5 alpha-spirostan-9(11)-en-3 beta, 12 beta, 17 alpha-triol (6) by physicochemical properties and spectroscopic methods. In addition, all of the compounds had their cytotoxic activities tested against U87MG and HepG2 tumour cells by the MTT method. Compounds 3 and 6 showed moderate inhibitory effects against the U87MG cells with IC50 values of 15.5 mu M and 27.2 mu M, respectively, while compounds 1-6 showed different inhibitory effects against the HepG2 cells with IC50, values of 9.8 to 56.3 mu M, respectively.

引用

页码：173 / 177

页数：5

共 20 条

[1]

ALLEY MC, 1988, CANCER RES, V48, P589

[2] Two new compounds from the roots and rhizomes of Trillium tschonoskii [J].

Chai, Jiang ;

Song, Xiaomei ;

Wang, Xin ;

Mei, Qibing ;

Li, Zhao ;

Cui, Jiucheng ;

Tang, Zhishu ;

Yue, Zhenggang .

PHYTOCHEMISTRY LETTERS, 2014, 10 :113-117

[3]

Cui Y., 2018, MOLECULES, V23, P708

[4] Steroidal saponins from the leaves of Beaucarnea recurvata [J].

Eskander, Jacqueline ;

Lavaud, Catherine ;

Harakat, Dominique .

PHYTOCHEMISTRY, 2011, 72 (09) :946-951

[5]

Ji Chenchen, 2015, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, V31, P484

[6] Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum [J].

Lee, Chia-Lin ;

Hwang, Tsong-Long ;

He, Wan-Jung ;

Tsai, Yi-Hong ;

Yen, Chiao-Ting ;

Yen, Hsin-Fu ;

Chen, Chao-Jung ;

Chang, Wei-Yi ;

Wu, Yang-Chang .

PHYTOCHEMISTRY, 2013, 95 :315-321

[7] Steroidal Saponins from the Roots and Rhizomes of Tupistra chinensis [J].

Li, Yuze ;

Wang, Xin ;

He, Hao ;

Zhang, Dongdong ;

Jiang, Yi ;

Yang, Xinjie ;

Wang, Fei ;

Tang, Zhishu ;

Song, Xiaomei ;

Yue, Zhenggang .

MOLECULES, 2015, 20 (08) :13659-13669

[8] Steroidal saponins from Smilacina japonica [J].

Liu, Xia ;

Zhang, Hui ;

Niu, Xiao-Feng ;

Xin, Wei ;

Qi, Lin .

FITOTERAPIA, 2012, 83 (04) :812-816

[9] Spirostanol tetraglycosides from Ypsilandra thibetica [J].

Lu, Yi ;

Chen, Chang-Xiang ;

Ni, Wei ;

Hua, Yan ;

Liu, Hai-Yang .

STEROIDS, 2010, 75 (12) :982-987

[10] Bioactive steroidal saponins from Agave offoyana flowers [J].

Perez, Andy J. ;

Calle, Juan M. ;

Simonet, Ana M. ;

Guerra, Jose O. ;

Stochmal, Anna ;

Macias, Francisco A. .

PHYTOCHEMISTRY, 2013, 95 :298-307

← 1 2 →