Antioxidant properties of chitosan-(poly)nitroxides under induced oxidative stress

被引：9

作者：

Balakina, A. A. ^{[1
,2
,3
]}

Mumyatova, V. A. ^{[1
,2
,3
]}

Pliss, E. M. ^{[2
]}

Terent'ev, A. A. ^{[1
,2
,3
,4
]}

Sen', V. D. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, 1 Prosp Akad Semenova, Chernogolovka 142432, Moscow Region, Russia

[2] PG Demidov Yaroslavl State Univ, 14 Sovetskaya Ul, Yaroslavl 150003, Russia

[3] Moscow Reg State Univ, Res & Educ Ctr Med Chem Chernogolovka, 24 Ul Very Voloshinoi, Mytishchi 141014, Moscow Region, Russia

[4] Moscow MV Lomonosov State Univ, Fac Fundamental Phys & Chem Engn, Build 51,1 Leninskie Gory, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2018年 / 67卷 / 11期

基金：

俄罗斯科学基金会;

关键词：

chitosan; nitroxide radicals; chitosan-(poly)nitroxides; cytotoxicity; oxidative stress; reactive oxygen species; malondialdehyde; RAPID COLORIMETRIC ASSAY; CHITOSAN; DERIVATIVES; CELLS; NITROXIDE; SURVIVAL; GROWTH;

D O I：

10.1007/s11172-018-2341-y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cytotoxicity and antioxidant properties of water-soluble (at physiological pH) chitosan- (poly)nitroxides (CPNs) containing pyrroline-based nitroxide and having different molecular weights of the polysaccharide backbone were studied on normal (Vero) and tumor (HepG2) cell models. The compounds were found to exhibit low cytotoxicity and to effectively reduce the level of reactive oxygen species (ROS) generated upon the breakdown of tert-butyl hydroperoxide in normal cells. In tumor cells, the CPNs have little effect on the ROS level under the oxidative stress. The results show that CPNs also represent a promising platform for the development of cell delivery systems for biologically active compounds.

引用

页码：2135 / 2140

页数：6

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