Cellular transformation by human T-cell leukemia virus type I

被引：1

作者：

Ressler, S ^{[1
]}

Connor, LM ^{[1
]}

Marriott, SJ ^{[1
]}

机构：

[1] BAYLOR COLL MED,DIV MOLEC VIROL,HOUSTON,TX 77030

来源：

FEMS MICROBIOLOGY LETTERS | 1996年 / 140卷 / 2-3期

关键词：

retrovirus; HTLV-I; transformation; Tax; transcription activator; T-cell leukemia;

D O I：

10.1016/0378-1097(96)00166-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human T-cell leukemia virus type I (HTLV-I) is an oncogenic retrovirus that was isolated in 1980 from a patient with adult T-cell leukemia. From numerous experiments using infected patient T-cells, transgenic mice and tissue culture transformation assays, the Tax protein has been determined to be the transforming component of HTLV-I. Tax-mediated transformation is linked to its ability to transcriptionally regulate the expression of cellular genes involved in growth and proliferation. Ultimately, unregulated and continued activation of these important growth modulating genes by Tax leads to transformation.

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收藏

页码：99 / 109

页数：11

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