DJ-1 and Parkinson's Disease

被引：1

作者：

Qi Ting-Ting ^{[1
]}

Lin Lin ^{[1
]}

Liu Yun ^{[1
]}

Jiang Yong ^{[1
]}

机构：

[1] So Med Univ, Key Lab Funct Prote Guangdong Prov, Dept Pathophysiol, Guangzhou 510515, Guangdong, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2011年 / 38卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Parkinson's disease; DJ-1; oxidative stress; CYSTEINE-SULFINIC ACID; MITOCHONDRIAL LOCALIZATION; CRYSTAL-STRUCTURE; PROTEIN DJ-1; ACTIVATION; PARK7; GENE; SUMOYLATION; MUTATIONS; OXIDATION;

D O I：

10.3724/SP.J.1206.2010.00393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Located in the cytoplasm, mitochondria and nucleus in the form of soluble dimers, DJ-1 is a recognized Parkinson's disease (PD)-related protein since its gene mutation leads to the early onset of autosomal recessive PD. Under oxidative stress which is closely related to the pathogenesis of PD, DJ-1 exerts its neuroprotective effects by sensing oxidative stress, changing gene expression, and participating in the regulation of AKT, ASK and other important signaling pathways.

引用

页码：293 / 298

页数：6

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