The effect of influenza vaccination on risk of acute myocardial infarction: Self-controlled case-series study

被引：53

作者：

Gwini, Stella M. ^{[1
]}

Coupland, Carol A. C. ^{[2
]}

Siriwardena, Aloysius N. ^{[3
,4
]}

机构：

[1] Monash Univ, DEPM Ctr Occupat & Environm Hlth, Melbourne, Vic 3004, Australia

[2] Univ Nottingham, Div Primary Care, Sch Community Hlth Sci, Nottingham NG7 2RD, England

[3] Lincoln Univ, Fac Hlth Life & Social Sci, Lincoln LN6 7TS, England

[4] NHS Lincolnshire, Fac Hlth Life & Social Sci, Lincoln LN6 7TS, England

来源：

VACCINE | 2011年 / 29卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Myocardial infarction; Influenza vaccination; Self-controlled case series design; RESPIRATORY-TRACT INFECTIONS; PRACTICE RESEARCH DATABASE; CORONARY-ARTERY-DISEASE; SERUM ANTIBODY-RESPONSE; CARDIOVASCULAR-DISEASE; IMMUNE-RESPONSE; MORTALITY; EVENTS; TIME; ASSOCIATION;

D O I：

10.1016/j.vaccine.2010.12.017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Acute myocardial infarction (AMI) peaks in winter months, partly linked to epidemic influenza. This implies that influenza vaccination may prevent some cases of AMI. This study investigated the association between influenza vaccination and AMI using the self-controlled case-series method. We identified 8180 cases of first AMI aged 40 years and over at time of diagnosis. The incidence of AMI was significantly reduced in the 60 days following vaccination (compared with the baseline period), ranging from a reduction of 32% (IRR 0.68; 95% CI 0.60-0.78) at 1-14 days after vaccination, to 18% (IRR 0.82; 95% CI 0.75-0.90) at 29-59 days after vaccination. Reductions in AMI incidence were more pronounced for early seasonal vaccinations before mid-November. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1145 / 1149

页数：5

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