In Vitro Activity of Plazomicin against Gram-Negative and Gram-Positive Bacterial Pathogens Isolated from Patients in Canadian Hospitals from 2013 to 2017 as Part of the CANWARD Surveillance Study

被引:21
作者
Walkty, Andrew [1 ,2 ]
Karlowsky, James A. [1 ,2 ]
Baxter, Melanie R. [1 ]
Adam, Heather J. [1 ,2 ]
Zhanel, George G. [1 ]
机构
[1] Univ Manitoba, Max Rady Coll Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada
[2] Shared Hlth, Winnipeg, MB, Canada
关键词
aminoglycosides; Gram-negative bacteria; Gram-positive bacteria; multidrug resistance; plazomicin; ANTIMICROBIAL ACTIVITY; AMINOGLYCOSIDE; ENTEROBACTERIACEAE; RESISTANCE; ACHN-490;
D O I
10.1128/AAC.02068-18
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The Clinical and Laboratory Standards Institute (CLSI) broth microdilution method was used to evaluate the in vitro activities of plazomicin and comparator antimicrobial agents against 7,712 Gram-negative and 4,481 Gram-positive bacterial pathogens obtained from 2013 to 2017 from patients in Canadian hospitals as part of the CANWARD Surveillance Study. Plazomicin demonstrated potent in vitro activity against Enterobacteriaceae (MIC90 <= 1 mu g/ml for all species tested except Proteus mirabilis and Morganella morganii), including aminoglycoside-nonsusceptible, extended-spectrum beta-lactamase (ESBL)-positive, and multidrug-resistant (MDR) isolates. Plazomicin was equally active against methicillin-susceptible and methicillin-resistant isolates of Staphylococcus aureus.
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页数:10
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