Mitochondrial dysfunction and Alzheimer's disease

被引：102

作者：

Maruszak, Aleksandra ^{[1
]}

Zekanowski, Cezary ^{[1
]}

机构：

[1] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neurodegenerat Disorders, PL-02106 Warsaw, Poland

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2011年 / 35卷 / 02期

关键词：

Alzheimer's disease; APOE4; Mitochondrial DNA (mtDNA); Mitochondrial dysfunction; Mitochondrial haplogroups; Oxidative stress; CYTOCHROME-C-OXIDASE; AMYLOID PRECURSOR PROTEIN; KETOGLUTARATE DEHYDROGENASE COMPLEX; OXIDATIVELY MODIFIED PROTEINS; MILD COGNITIVE IMPAIRMENT; APOLIPOPROTEIN-E GENOTYPE; OXYGEN SPECIES PRODUCTION; MATERNAL FAMILY-HISTORY; FREE-RADICAL GENERATION; MTDNA CONTROL-REGION;

D O I：

10.1016/j.pnpbp.2010.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To date, one of the most discussed hypotheses for Alzheimer's disease (AD) etiology implicates mitochondrial dysfunction and oxidative stress as one of the primary events in the course of AD. In this review we focus on the role of mitochondria and mitochondrial DNA (mtDNA) variation in AD and discuss the rationale for the involvement of mitochondrial abnormalities in AD pathology. We summarize the current data regarding the proteins involved in mitochondrial function and pathology observed in AD, and discuss the role of somatic mutations and mitochondrial haplogroups in AD development. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：320 / 330

页数：11

共 194 条

[1] Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease [J].

Abe, T ;

Tohgi, H ;

Isobe, C ;

Murata, T ;

Sato, C .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) :447-450

[2] Protein oxidation in the brain in Alzheimer's disease [J].

Aksenov, MY ;

Aksenova, MV ;

Butterfield, DA ;

Geddes, JW ;

Markesbery, WR .

NEUROSCIENCE, 2001, 103 (02) :373-383

[3] Mitochondria and Alzheimer's disease: amyloid-β peptide uptake and degradation by the presequence protease, hPreP [J].

Alikhani, Nyosha ;

Ankarcrona, Maria ;

Glaser, Elzbieta .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2009, 41 (05) :447-451

[4] New Population and Phylogenetic Features of the Internal Variation within Mitochondrial DNA Macro-Haplogroup R0 [J].

Alvarez-Iglesias, Vanesa ;

Mosquera-Miguel, Ana ;

Cerezo, Maria ;

Quintans, Beatriz ;

Teresa Zarrabeitia, Maria ;

Cusco, Ivon ;

Victoria Lareu, Maria ;

Garcia, Oscar ;

Perez-Jurado, Luis ;

Carracedo, Angel ;

Salas, Antonio .

PLOS ONE, 2009, 4 (04)

[5] Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease [J].

Anandatheerthavarada, Hindupur K. ;

Devi, Latha .

NEUROSCIENTIST, 2007, 13 (06) :626-638

[6] Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells [J].

Anandatheerthavarada, HK ;

Biswas, G ;

Robin, MA ;

Avadhani, NG .

JOURNAL OF CELL BIOLOGY, 2003, 161 (01) :41-54

[7] A role for heme in Alzheimer's disease:: Heme binds amyloid β and has altered metabolism [J].

Atamna, H ;

Frey, WH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (30) :11153-11158

[8] Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease [J].

Atamna, Ham ;

Frey, William H., II .

MITOCHONDRION, 2007, 7 (05) :297-310

[9] Amyloid-β:: a chameleon walking in two worlds:: a review of the trophic and toxic properties of amyloid-β [J].

Atwood, CS ;

Obrenovich, ME ;

Liu, TB ;

Chan, H ;

Perry, G ;

Smith, MA ;

Martins, RN .

BRAIN RESEARCH REVIEWS, 2003, 43 (01) :1-16

[10]

Baloyannis SJ, 2006, J ALZHEIMERS DIS, V9, P119

← 1 2 3 4 5 6 7 8 9 10 →