A red-emissive benzothiazole-based luminophore with ESIPT and AIE natures and its application for detecting and imaging hypochlorous acid

被引：15
作者：
Li, Siyun [1 ]
Zeng, Ying [1 ]
Tang, Can [1 ]
Wang, Feifei [1 ]
Gu, Biao [1 ]
Tang, Siping [1 ]
机构：
[1] Hengyang Normal Univ, Coll Chem & Mat Sci, Key Lab Chem Sensing & Catalysis, Hengyang Key Lab New Detect Technol & Biol Agents, Hengyang 421008, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2022年 / 281卷
基金：
中国国家自然科学基金;
关键词：
ESIPT plus AIE; HClO chemosensor; Red emission; Large Stokes shift; Cell imaging; FLUORESCENT-PROBES; MITOCHONDRIA;
D O I：
10.1016/j.saa.2022.121601
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A new "ESIPT + AIE" based dye of benzothiazole with red emission and a large Stokes shift was constructed by combining 2-(2'-hydroxyphenyl)benzothiazole as the ESIPT unit and alpha-cyanostilbene as the AIE unit. The compound BACN was found to be a ideal HClO chemosensor, and presented palpable fluorescence and colorimetric responses toward HClO via the HClO-trigged oxidation cleavage of the ethylene bridge activated by the electron withdrawing cyano group. BACN was capable of recognizing HClO rapidly (12 s) and sensitively under physiological conditions, with good selectivity over other biologically pertinent substances. Thanks to strong red emission (lambda(em) = 606 nm) and large Stokes shift (213 nm) resulted from the combination of ESIPT and AIE effects, it was successfully utilized for the recognition of exogenous and endogenous HClO in living HeLa cells.
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页数：7
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