Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Mali: a systematic review and meta-analysis

被引：18

作者：

Maiga, Fatoumata O. ^{[1
]}

Wele, Mamadou ^{[1
]}

Toure, Sounkou M. ^{[1
]}

Keita, Makan ^{[1
]}

Tangara, Cheick Oumar ^{[1
]}

Refeld, Randi R. ^{[2
]}

Thiero, Oumar ^{[1
]}

Kayentao, Kassoum ^{[1
]}

Diakite, Mahamadou ^{[1
]}

Dara, Antoine ^{[1
]}

Li, Jian ^{[2
]}

Toure, Mahamoudou ^{[1
]}

Sagara, Issaka ^{[1
]}

Djimde, Abdoulaye ^{[1
]}

Mather, Frances J. ^{[2
]}

Doumbia, Seydou O. ^{[1
]}

Shaffer, Jeffrey G. ^{[2
]}

机构：

[1] Univ Sci Tech & Technol Bamako, Bamako, Mali

[2] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Biostat & Data Sci, 1440 Canal St 8310,Suite 1610, New Orleans, LA 70112 USA

来源：

MALARIA JOURNAL | 2021年 / 20卷 / 01期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

Artemether-lumefantrine; Artemisinin-based combination therapy; Malaria; Mali; Systematic review; ARTEMETHER-LUMEFANTRINE; ANTIMALARIAL-DRUG; RANDOMIZED-TRIAL; ARTESUNATE; RESISTANCE; EFFICACY; SAFETY; PYRIMETHAMINE; AQ-13;

D O I：

10.1186/s12936-021-03890-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background Artemisinin-based combination therapy (ACT) was deployed in 2005 as an alternative to chloroquine and is considered the most efficacious treatment currently available for uncomplicated falciparum malaria. While widespread artemisinin resistance has not been reported to date in Africa, recent studies have reported partial resistance in Rwanda. The purpose of this study is to provide a current systematic review and meta-analysis on ACT at Mali study sites, where falciparum malaria is highly endemic. Methods A systematic review of the literature maintained in the bibliographic databases accessible through the PubMed, ScienceDirect and Web of Science search engines was performed to identify research studies on ACT occurring at Mali study sites. Selected studies included trials occurring at Mali study sites with reported polymerase chain reaction (PCR)-corrected adequate clinical and parasite response rates (ACPRcs) at 28 days. Data were stratified by treatment arm (artemether-lumefantrine (AL), the first-line treatment for falciparum malaria in Mali and non-AL arms) and analysed using random-effects, meta-analysis approaches. Results A total of 11 studies met the inclusion criteria, and a risk of bias assessment carried out by two independent reviewers determined low risk of bias among all assessed criteria. The ACPRc for the first-line AL at Mali sites was 99.0% (95% CI (98.3%, 99.8%)), while the ACPRc among non-AL treatment arms was 98.9% (95% CI (98.3%, 99.5%)). The difference in ACPRcs between non-AL treatment arms and AL treatment arms was not statistically significant (p = .752), suggesting that there are potential treatment alternatives beyond the first-line of AL in Mali. Conclusions ACT remains highly efficacious in treating uncomplicated falciparum malaria in Mali. Country-specific meta-analyses on ACT are needed on an ongoing basis for monitoring and evaluating drug efficacy patterns to guide local malaria treatment policies, particularly in the wake of observed artemisinin resistance in Southeast Asia and partial resistance in Rwanda.

引用

页数：13

共 63 条

[1] Efficacy and safety of artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Sudan: a systematic review and meta-analysis [J].