Effect of quinocitrinines from the fungus Penicillium citrinum on the respiration of yeasts and bacteria

被引：5
|
作者：
Arinbasarova, A. Yu. [1 ]
Medentsev, A. G. [1 ]
Kozlovskii, A. G. [1 ]
机构：
[1] Russian Acad Sci, Skryabin Inst Biochen & Physiol Microorganisms, Pushchino 142290, Russia
来源：
APPLIED BIOCHEMISTRY AND MICROBIOLOGY | 2007年 / 43卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
D O I：
10.1134/S0003683807060105
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We studied the effect of quinocitrinines on the respiratory activity of yeasts (Yarrowia lipolytica) and bacteria (Arthrobacter globiformnis). Quinocitrinines were shown to activate respiration of native cells in both types of organisms. Studies of yeast mitochondria showed that quinocitrinine exerts an uncoupling effect on oxidative phosphorylation, which activates the respiration, reduces the respiratory control, and decreases the ADP/O ratio. Experiments with intact mitochondria and native cells of Arthrobacter globiformis revealed that quinocitrinine decreases the membrane potential. The uncoupling effect likely constitutes a mechanism of the antibiotic activity of quinocitrinines.
引用
收藏
页码：625 / 628
页数：4
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