Neuroprotective Effects of Immobilized Granulocyte Colony-Stimulating Factor and Hyaluronidase

被引：0

作者：

Andreeva, T. V. ^{[1
]}

Vereshagin, E. I. ^{[2
]}

Ermakova, N. N. ^{[1
]}

Madonov, P. G. ^{[2
]}

Pershina, O. V. ^{[1
]}

Skurikhin, E. G. ^{[1
]}

Zjuzkov, G. N. ^{[1
]}

Minakova, M. Ju. ^{[1
]}

Khmelevskaya, E. S. ^{[1
]}

Dygai, A. M. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Inst Pharmacol, Siberian Div, Tomsk, Russia

[2] Sci Futures Management Co, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2010年 / 149卷 / 04期

关键词：

encephalopathy; immobilized granulocyte colony-stimulating factor; hyaluronidase; hypoxia;

D O I：

10.1007/s10517-010-0960-x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Neuroprotective activity of immobilized granulocyte CSF (nanotechnology with electron-beam synthesis) and hyaluronidase was studied on the model of posthypoxic encephalopathy. Oral administration of immobilized granulocyte CSF had no effect on manifestations of posthypoxic psychoneurological disorders in animals. Combined treatment with immobilized granulocyte CSF and hyaluronidase prevented impairment of orientation and exploratory behavior and development of amnesia in mice with hypoxic injury.

引用

页码：421 / 424

页数：4

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