Discrepancy in Programmed Cell Death-Ligand 1 Between Primary and Metastatic Non-small Cell Lung Cancer

被引：33

作者：

Takamori, Shinkichi ^{[1
]}

Toyokawa, Gouji ^{[1
]}

Okamoto, Isamu ^{[2
]}

Takada, Kazuki ^{[1
,3
]}

Kozuma, Yuka ^{[1
]}

Matsubara, Taichi ^{[1
]}

Haratake, Naoki ^{[1
]}

Akamine, Takaki ^{[1
]}

Katsura, Masakazu ^{[1
]}

Mukae, Nobutaka ^{[4
]}

Shoji, Fumihiro ^{[1
]}

Okamoto, Tatsuro ^{[1
]}

Oda, Yoshinao ^{[3
]}

Iwaki, Toru ^{[5
]}

Iihara, Koji ^{[4
]}

Nakanishi, Yoichi ^{[2
]}

Maehara, Yoshihiko ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Fukuoka 8128582, Japan

[2] Kyushu Univ, Chest Grad Sch Med Sci, Res Inst Dis, Fukuoka, Japan

[3] Kyushu Univ, Dept Anat Pathol, Grad Sch Med Sci, Fukuoka, Japan

[4] Kyushu Univ, Dept Neurosurg, Grad Sch Med Sci, Fukuoka, Japan

[5] Kyushu Univ, Dept Neuropathol, Neurol Inst, Grad Sch Med Sci, Fukuoka, Japan

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 08期

关键词：

Programmed cell death-ligand 1; immunotherapy; non-small cell lung cancer; BRAIN METASTASES; PREDICTIVE BIOMARKERS; EXPRESSION; PD-L1; PEMBROLIZUMAB; ALECTINIB; NIVOLUMAB; ERLOTINIB; CHEMOTHERAPY; CRIZOTINIB;

D O I：

10.21873/anticanres.11813

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To investigate the discordance in the programmed cell death-ligand 1 (PD-L1) expression between primary and metastatic tumors and analyze the association between the discordance and the clinical factors in non-small cell lung cancer (NSCLC) patients. Patients and Methods: Twenty-one NSCLC patients who underwent surgery or biopsy for paired primary and metastatic lesions at our Institution from 2005 to 2016 were analyzed. Lesions with the PD-L1 expression being >= 5% were considered PD-L1-positive. Results: The metastatic sites included the brain (n=16), adrenal gland (n=3), spleen (n=1) and jejunum (n=1). Negative conversion of the primary PD-L1-positive NSCLC and positive conversion of the primary PD-L1-negative NSCLC were observed in 3 (14%) and 2 (10%) cases, respectively. Radiotherapy for the metastatic brain lesion before its resection showed a significant relationship with the positive conversion of the primary PD-L1-negative NSCLC (p=0.048). Conclusion: Radiotherapy-derived effects may contribute to the positive conversion of the primary PD-L1-negative NSCLC.

引用

页码：4223 / 4228

页数：6

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