Koanolides B-D, new sesquiterpene lactones from Koanophyllon gibbosum

被引：2

作者：

Castillo, Quirico A. ^{[1
,2
]}

Padron, Jose M. ^{[3
]}

Keramane, Mehdi ^{[4
]}

机构：

[1] Univ Autonoma Santo Domingo UASD, Fac Ciencias, Escuela Quim, Ciudad Univ, Santo Domingo, DN, Dominican Rep

[2] Univ Autonoma Santo Domingo UASD, Fac Ciencias, Inst Quim, Ciudad Univ, Santo Domingo, DN, Dominican Rep

[3] Univ La Laguna, Inst Univ Bioorgan Antonio Gonzalez IUBO AG, BioLab, San Cristobal la Laguna 38206, Spain

[4] McMaster Univ, Biointerfaces Inst, Engn Technol Bldg,Room 413,1280 Main St West, Hamilton, ON L8S 0A3, Canada

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 47卷

关键词：

Koanophyllon gibbosum; Koanolides B-D; Sesquiterpene lactones; Asteraceae;

D O I：

10.1016/j.phytol.2021.11.009

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new germacrane-type sesquiterpene lactones, koanolides B-D (1-3) have been isolated from the aerial parts of Koanophyllon gibbosum (Asteraceae), along with the previously reported sesquiterpene lactone koanolide A and the flavonoid eupatorin. The structures of the new compounds were elucidated using spectroscopic and spectrometric data analyses, including 1D and 2D NMR, and by comparison with known spectral data. The antiproliferative activities of the new compounds were evaluated in a panel of six representative human solid tumor cell lines and showed GI(50) values ranging from 1.3 to 16 mu M for the new molecules.

引用

页码：63 / 66

页数：4

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