Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

被引：253

作者：

Dodelet, VC ^{[1
]}

Pasquale, EB ^{[1
]}

机构：

[1] Burnham Inst, La Jolla, CA 92037 USA

来源：

ONCOGENE | 2000年 / 19卷 / 49期

基金：

美国国家卫生研究院;

关键词：

receptor tyrosine kinase; tissue patterning; axon guidance; cell segregation; angiogenesis;

D O I：

10.1038/sj.onc.1203856

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein tyrosine kinase genes are the largest family of oncogenes, This is not surprising since tyrosine kinases are important components of signal transduction pathways that control cell shape, proliferation, differentiation, and migration, At 14 distinct members, the Eph kinases constitute the largest family of receptor tyrosine kinases, Although they have been most intensively studied for their roles in embryonic development, increasing evidence also implicates Eph family proteins in cancer. This review will address the recent progress in understanding the function of Eph receptors in normal development and how disregulation of these functions could promote tumorigenesis.

引用

页码：5614 / 5619

页数：6

共 78 条

[1] Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis [J].