PKC and CaMKII dependent synaptic potentiation in cultured cerebral neurons

被引：17
作者：
Kudoh, SN [1 ]
Nagai, R [1 ]
Kiyosue, K [1 ]
Taguchi, T [1 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Special Div Human Life Technol, Neuron Res Grp, Ikeda, Osaka 5638577, Japan
来源：
BRAIN RESEARCH | 2001年 / 915卷 / 01期
关键词：
synaptic potentiation; PKC; CaMKII; culture system; protein factor;
D O I：
10.1016/S0006-8993(01)02835-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have reported that the long-lasting potentiation of spontaneous excitatory postsynaptic currents (SEPSCs) was induced by a Mg2+-free treatment in cultured chick cerebral neurons and a factor(s) extracellularly released during the treatment could induce the potentiation by itself. In this paper, protein kinase C (PKC) and calcium/ calmodulin-dependent protein kinase type II (CaMKII) but not protein kinase A (PKA) were reported to contribute to the potentiation mechanism during a step between the activation of the N-methyl-D-aspartate receptors by the Mg2+-free treatment and the secretion of the protein factor(s). (C) 2001 Elsevier Science BY. All rights reserved.
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收藏
页码：79 / 87
页数：9
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