Asthma-Alleviating Potential of 6-Gingerol: Effect on Cytokines, Related mRNA and c-Myc, and NFAT1 Expression in Ovalbumin-Sensitized Asthma in Rats

被引：7

作者：

Li Zaoni ^{[1
]}

Liu Zhongxi ^{[2
]}

Uddandrao, V. V. Sathibabu ^{[3
]}

Ponnusamy, Ponmurugan ^{[4
]}

Balakrishnan, Santhanaraj ^{[5
,6
]}

Brahmanaidu, P. ^{[7
]}

Vadivukkarasi, S. ^{[3
]}

Saravanan, Ganapathy ^{[3
]}

机构：

[1] Shangluo Cent Hosp, Med Clin, Shangluo 726000, Shaanxi, Peoples R China

[2] Daqing Oilfield Gen Hosp, Dept Resp Med, Daqing 163000, Heilongjiang, Peoples R China

[3] KS Rangasamy Coll Arts & Sci Autonomous, Ctr Biol Sci, Dept Biochem, Tiruchengode 637215, Tamil Nadu, India

[4] Bharathiar Univ, Dept Bot, Coimbatore 641046, Tamil Nadu, India

[5] Majmaah Univ, Coll Appl Med Sci, Al Majmaah 15341, Saudi Arabia

[6] Velalar Coll Engn & Technol, Dept Biomed Engn, Erode 638012, Tamil Nadu, India

[7] ICMR NARFBR, Hyderabad 500007, Telangana, India

来源：

JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY | 2019年 / 38卷 / 01期

关键词：

6-gingerol; asthma; natural products; lung disorders; AIRWAY INFLAMMATION; MOUSE MODEL; HYPERRESPONSIVENESS; CELLS;

D O I：

10.1615/JEnvironPatholToxicolOncol.2018027172

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

In this study, we aimed at assessing the therapeutical potential of 6-gingerol ([5S]-5-hydroxy-144-hydroxy-3-methoxyphenyl]-3-decanone) against ovalbumin-sensitized asthma in rats. The rats were treated intraperitoneally with 6-gingerol (75 mg/kg body weight) for 30 days and a theophylline (200 mg/kg body weight)-treated group as a control. Changes in the levels of T-cell-linked cytokines (interleukin-4 [IL-4], IL-5, IL-13, and interferon-gamma [IFN-gamma]), total immtmoglobulin E (IgE), gene expressions of bitter taste-sensing type 2-receptor 10 (T2R10), inositol 1,4,5-triphosphate receptor 1 (IP3R1), Orai 1 and protein expressions of nuclear factor of activated T cells 1 (NTATI), c-Myc and histopathological changes were observed in rats. 6-Gingerol exerts its beneficial impacts like theophylline in lessening IL-4, IL-5, and IL-13, and IgE and increasing the level of IFN-gamma. Significant down-regulation of T2R10 gene expression and up-regulation of IP3R1 and Orai 1 gene expression were observed in experimental rats and these alterations were normalized after treatment with 6-gingerol or theophylline. The histopathological study revealed that the accumulation of glycoprotein and thickness of alveolar epithelium in asthmatic rats and supplementation with 6-gingerol or theophylline in asthmatic rats restored these changes to normal. In conclusion, 6-gingerol has a protective effect on lungs in ovalbwnin-sensitized asthma in rats.

引用

页码：41 / 50

页数：10