Diphencyprone in the management of refractory palmoplantar and periungual warts: An open study

Background: Induction of delayed-type hypersensitivity has recently been introduced for resistant viral warts. The method is not painful and less destructive than most other modalities. Objective: We assessed the efficacy of topical diphencyprone (diphenylcyclopropenone) treatment for recalcitrant warts. Methods: From September 1988 to June 1995, 134 patients with periungual and/or palmoplantar warts were entered into the study. Eight weekly applications were delivered. Results: The scheduled treatment course and follow-up were completed by 111 patients. There were 49 complete and Is partial remissions. The rate of positive responders (60%) compares with the results published by other authors. Conclusion: Diphencyprone is an effective treatment for resistant warts, especially in palmoplantar and periungual locations.