Elemental and Structural Studies at the Bone-Cartilage Interface

被引：2

作者：

Bradley, D. A. ^{[1
]}

Kaabar, W. ^{[1
]}

Gundogdu, O. ^{[2
]}

机构：

[1] Univ Surrey, Dept Phys, Guildford GU2 7XH, Surrey, England

[2] Kochi Univ, Umuttepe Campus, TR-41380 Kocaeli, Turkey

来源：

IX LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS | 2012年 / 1423卷

关键词：

Biological Information; Musculoskeletal Diseases; Biomedical Imaging; RAY-FLUORESCENCE TECHNIQUE; ARTICULAR-CARTILAGE; MICROSCOPY; DEPOSITION;

D O I：

10.1063/1.3688820

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The techniques mu Proton-Induced X- and gamma-ray Emission, mu-PIXE and mu-PIGE, were used to investigate trace and essential element distributions in sections of normal and osteoarthritic (OA) human femoral head. mu-PIGE yielded 2-D mappings of Na and F while Ca, Z, P and S were mapped by mu-PIXE. The concentration of chondroitin sulphate supporting functionality in healthy cartilage is significantly reduced in OA samples. Localised Zn points to osteoblastic/osteoclastic activity at the bone-cartilage interface. Small-angle X-ray scattering applied to decalcified OA-affected tissue showed spatial alterations of collagen fibres of decreased axial periodicity compared to normal collagen type I.

引用

页数：8

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