Genetic determinants of glucose homeostasis

被引：10
作者：
Barker, Adam [1 ]
Langenberg, Claudia [1 ]
Wareham, Nicholas J. [1 ]
机构：
[1] Addenbrookes Hosp, MRC, Epidemiol Unit, Inst Metab Sci, Cambridge CB2 0QQ, England
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2012年 / 26卷 / 02期
基金：
英国医学研究理事会;
关键词：
fasting glucose; OGTT; insulin secretion; insulin resistance; GWAS; 2-h glucose; HbA(1c); genetics; SNP; GENOME-WIDE ASSOCIATION; BETA-CELL FUNCTION; LIPOPROTEIN-LIPASE GENE; FASTING PLASMA-GLUCOSE; TYPE-2 DIABETES RISK; INSULIN-RESISTANCE; SUSCEPTIBILITY LOCI; COMMON VARIANTS; PHYSIOLOGICAL CHARACTERIZATION; METABOLIC TRAITS;
D O I：
10.1016/j.beem.2011.12.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes is a complex metabolic disorder characterised by varying degrees of impairment in insulin secretion and resistance to the action of insulin. Considerable progress has been made recently in understanding the genetic determinants of diabetes. A logical next step is to describe how these variants relate to the underlying pathophysiological processes that lead to diabetes as this may provide insights into pathways to disease. These quantitative traits are, of course, of direct interest in themselves and a growing literature is now emerging on the genetic determinants of insulin secretion and insulin resistance. This review article focuses on describing the complex associations between type 2 diabetes risk variants and quantitative glycaemic traits and the relationship between variants initially discovered in association studies of these traits and risk of type 2 diabetes. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：159 / 170
页数：12
相关论文
共 88 条
  • [1] FABP2 Ala54Thr polymorphism and diabetes in Chilean elders
    Albala, Cecilia
    Villarroel, Ana
    Santos, Jose Luis
    Angel, Barbara
    Lera, Lydia
    Liberman, Claudio
    Sanchez, Hugo
    Perez-Bravo, Francisco
    [J]. DIABETES RESEARCH AND CLINICAL PRACTICE, 2007, 77 (02) : 245 - 250
  • [2] The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    Altshuler, D
    Hirschhorn, JN
    Klannemark, M
    Lindgren, CM
    Vohl, MC
    Nemesh, J
    Lane, CR
    Schaffner, SF
    Bolk, S
    Brewer, C
    Tuomi, T
    Gaudet, D
    Hudson, TJ
    Daly, M
    Groop, L
    Lander, ES
    [J]. NATURE GENETICS, 2000, 26 (01) : 76 - 80
  • [3] Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children
    Barker, Adam
    Sharp, Stephen J.
    Timpson, Nicholas J.
    Bouatia-Naji, Nabila
    Warrington, Nicole M.
    Kanoni, Stavroula
    Beilin, Lawrence J.
    Brage, Soren
    Deloukas, Panos
    Evans, David M.
    Grontved, Anders
    Hassanali, Neelam
    Lawlor, Deborah A.
    Lecoeur, Cecile
    Loos, Ruth J. F.
    Lye, Stephen J.
    McCarthy, Mark I.
    Mori, Trevor A.
    Ndiaye, Ndeye Coumba
    Newnham, John P.
    Ntalla, Ioanna
    Pennell, Craig E.
    St Pourcain, Beate
    Prokopenko, Inga
    Ring, Susan M.
    Sattar, Naveed
    Visvikis-Siest, Sophie
    Dedoussis, George V.
    Palmer, Lyle J.
    Froguel, Philippe
    Smith, George Davey
    Ekelund, Ulf
    Wareham, Nicholas J.
    Langenberg, Claudia
    [J]. DIABETES, 2011, 60 (06) : 1805 - 1812
  • [4] A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels
    Bouatia-Naji, Nabila
    Rocheleau, Ghislain
    Van Lommel, Leentje
    Lemaire, Katleen
    Schuit, Frans
    Cavalcanti-Proenca, Christine
    Marchand, Marion
    Hartikainen, Anna-Liisa
    Sovio, Ulla
    De Graeve, Franck
    Rung, Johan
    Vaxillaire, Martine
    Tichet, Jean
    Marre, Michel
    Balkau, Beverley
    Weill, Jacques
    Elliott, Paul
    Jarvelin, Marjo-Riitta
    Meyre, David
    Polychronakos, Constantin
    Dina, Christian
    Sladek, Robert
    Froguel, Philippe
    [J]. SCIENCE, 2008, 320 (5879) : 1085 - 1088
  • [5] A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    Bouatia-Naji, Nabila
    Bonnefond, Amelie
    Cavalcanti-Proenca, Christine
    Sparso, Thomas
    Holmkvist, Johan
    Marchand, Marion
    Delplanque, Jerome
    Lobbens, Stephane
    Rocheleau, Ghislain
    Durand, Emmanuelle
    De Graeve, Franck
    Chevre, Jean-Claude
    Borch-Johnsen, Knut
    Hartikainen, Anna-Liisa
    Ruokonen, Aimo
    Tichet, Jean
    Marre, Michel
    Weill, Jacques
    Heude, Barbara
    Tauber, Maithe
    Lemaire, Katleen
    Schuit, Frans
    Elliott, Paul
    Jorgensen, Torben
    Charpentier, Guillaume
    Hadjadj, Samy
    Cauchi, Stephane
    Vaxillaire, Martine
    Sladek, Robert
    Visvikis-Siest, Sophie
    Balkau, Beverley
    Levy-Marchal, Claire
    Pattou, Francois
    Meyre, David
    Blakemore, Alexandra I. F.
    Jarvelin, Marjo-Riita
    Walley, Andrew J.
    Hansen, Torben
    Dina, Christian
    Pedersen, Oluf
    Froguel, Philippe
    [J]. NATURE GENETICS, 2009, 41 (01) : 89 - 94
  • [6] Common genetic variation near MC4R is associated with waist circumference and insulin resistance
    Chambers, John C.
    Elliott, Paul
    Zabaneh, Delilah
    Zhang, Weihua
    Li, Yun
    Froguel, Philippe
    Balding, David
    Scott, James
    Kooner, Jaspal S.
    [J]. NATURE GENETICS, 2008, 40 (06) : 716 - 718
  • [7] Chen Ming-wei, 2004, Zhonghua Yi Xue Yi Chuan Xue Za Zhi, V21, P29
  • [8] Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels
    Chen, Wei-Min
    Erdos, Michael R.
    Jackson, Anne U.
    Saxena, Richa
    Sanna, Serena
    Silver, Kristi D.
    Timpson, Nicholas J.
    Hansen, Torben
    Orru, Marco
    Piras, Maria Grazia
    Bonnycastle, Lori L.
    Willer, Cristen J.
    Lyssenko, Valeriya
    Shen, Haiqing
    Kuusisto, Johanna
    Ebrahim, Shah
    Sestu, Natascia
    Duren, William L.
    Spada, Maria Cristina
    Stringham, Heather M.
    Scott, Laura J.
    Olla, Nazario
    Swift, Amy J.
    Najjar, Samer
    Mitchell, Braxton D.
    Lawlor, Debbie A.
    Smith, George Davey
    Ben-Shlomo, Yoav
    Andersen, Gitte
    Borch-Johnsen, Knut
    Jorgensen, Torben
    Saramies, Jouko
    Valle, Timo T.
    Buchanan, Thomas A.
    Shuldiner, Alan R.
    Lakatta, Edward
    Bergman, Richard N.
    Uda, Manuela
    Tuomilehto, Jaakko
    Pedersen, Oluf
    Cao, Antonio
    Groop, Leif
    Mohlke, Karen L.
    Laakso, Markku
    Schlessinger, David
    Collins, Francis S.
    Altshuler, David
    Abecasis, Goncalo R.
    Boehnke, Michael
    Scuteri, Angelo
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (07) : 2620 - 2628
  • [9] Association of lipoprotein lipase (LPL) single nucleotide polymorphisms with type 2 diabetes mellitus
    Cho, Yoon Shin
    Go, Min Jin
    Han, Hye Ree
    Cha, Seung-Hun
    Kim, Hung-Tae
    Min, Haesook
    Shin, Hyoung Doo
    Park, Chan
    Han, Bok-Ghee
    Cho, Nam Han
    Shin, Chol
    Kimm, Kuchan
    Oh, Bermseok
    [J]. EXPERIMENTAL AND MOLECULAR MEDICINE, 2008, 40 (05) : 523 - 532
  • [10] Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits
    Craig, Rebekah L.
    Chu, Winston S.
    Elbein, Steven C.
    [J]. MOLECULAR GENETICS AND METABOLISM, 2007, 90 (03) : 338 - 344
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