Genetic determinants of glucose homeostasis

被引：10

作者：

Barker, Adam ^{[1
]}

Langenberg, Claudia ^{[1
]}

Wareham, Nicholas J. ^{[1
]}

机构：

[1] Addenbrookes Hosp, MRC, Epidemiol Unit, Inst Metab Sci, Cambridge CB2 0QQ, England

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2012年 / 26卷 / 02期

基金：

英国医学研究理事会;

关键词：

fasting glucose; OGTT; insulin secretion; insulin resistance; GWAS; 2-h glucose; HbA(1c); genetics; SNP; GENOME-WIDE ASSOCIATION; BETA-CELL FUNCTION; LIPOPROTEIN-LIPASE GENE; FASTING PLASMA-GLUCOSE; TYPE-2 DIABETES RISK; INSULIN-RESISTANCE; SUSCEPTIBILITY LOCI; COMMON VARIANTS; PHYSIOLOGICAL CHARACTERIZATION; METABOLIC TRAITS;

D O I：

10.1016/j.beem.2011.12.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes is a complex metabolic disorder characterised by varying degrees of impairment in insulin secretion and resistance to the action of insulin. Considerable progress has been made recently in understanding the genetic determinants of diabetes. A logical next step is to describe how these variants relate to the underlying pathophysiological processes that lead to diabetes as this may provide insights into pathways to disease. These quantitative traits are, of course, of direct interest in themselves and a growing literature is now emerging on the genetic determinants of insulin secretion and insulin resistance. This review article focuses on describing the complex associations between type 2 diabetes risk variants and quantitative glycaemic traits and the relationship between variants initially discovered in association studies of these traits and risk of type 2 diabetes. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：159 / 170

页数：12

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