Severity of stable coronary artery disease and its biomarkers differ between men and women undergoing angiography

被引：29
作者：
Gijsberts, Crystel M. [1 ,2 ]
Gohar, Aisha [1 ]
Ellenbroek, Guilielmus H. J. M. [1 ]
Hoefer, Imo E. [1 ]
de Kleijn, Dominique P. V. [1 ,2 ,6 ,7 ]
Asselbergs, Folkert W. [3 ,4 ,5 ]
Nathoe, Hendrik M. [3 ]
Agostoni, Pierfrancesco [3 ]
Rittersma, Saskia Z. H. [3 ]
Pasterkamp, Gerard [1 ]
Appelman, Yolande [8 ]
den Ruijter, Hester M. [1 ]
机构：
[1] Univ Med Ctr, Lab Expt Cardiol, Div Heart & Lungs, NL-3508 GA Utrecht, Netherlands
[2] ICIN Netherlands Heart Inst, Utrecht, Netherlands
[3] Univ Med Ctr, Div Heart & Lungs, Dept Cardiol, NL-3508 GA Utrecht, Netherlands
[4] ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands
[5] UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England
[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore 117595, Singapore
[7] Natl Univ Hlth Syst, Natl Univ Heart Ctr, Cardiovasc Res Inst, Singapore, Singapore
[8] Vrije Univ Amsterdam Med Ctr, Dept Cardiol, Amsterdam, Netherlands
来源：
ATHEROSCLEROSIS | 2015年 / 241卷 / 01期
关键词：
Epidemiology; Sex; Biomarkers; Coronary angiography; C-REACTIVE PROTEIN; SERUM CYSTATIN C; HEART-DISEASE; PLASMA-LEVELS; RISK-FACTORS; MICROVASCULAR DYSFUNCTION; CLINICAL UTILITY; SYNTAX SCORE; ATHEROSCLEROSIS; INFLAMMATION;
D O I：
10.1016/j.atherosclerosis.2015.02.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Coronary artery disease (CAD) affects both men and women. Cardiovascular biomarkers have been suggested to relate to CAD severity, but data on sex-specificity is scarce. Therefore, we investigated the association of established biomarkers with the severity of CAD in stable patients undergoing coronary angiography in a sex-specific manner. Methods: We studied stable patients undergoing coronary angiography and measured CAD severity by SYNTAX score and biomarker levels (N-terminal pro-brain natriuretic peptide (NT pro-BNP), high-sensitivity CRP (hsCRP), cystatin C (CysC), myeloperoxidase (MPO), high-sensitivity troponin I (hsTnI) and von Willebrand factor (VWF)). We tested for sex differences in SYNergy between percutaneous coronary intervention with TAXUS (TM) and cardiac surgery (SYNTAX) scores and biomarker levels using multivariable ANCOVA. We investigated the association of biomarker levels with SYNTAX score in a multivariable linear regression with interaction terms for sex. Results: We analysed data on 460 men and 175 women. SYNTAX scores were significantly lower in women (9.99 points vs. 11.88 points). Univariably, hsCRP and hsTnI levels were significantly associated with SYNTAX scores (both beta 2.5). In multivariable analysis only hsCRP associated with SYNTAX score (b 1.9, p = 0.009). Sex did not modify the association of biomarkers with SYNTAX score. Conclusion: CAD severity as quantified by SYNTAX score is lower in women than men based on coronary angiography. The association of biomarkers with CAD severity did not differ between the sexes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：234 / 240
页数：7
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