Effects of aldose reductase inhibitor in diabetic rats

被引：0
|
作者：
Nagai, T [1 ]
Sekizuka, E [1 ]
Tsukada, K [1 ]
Shimizu, T [1 ]
Minamitani, H [1 ]
Hokari, R [1 ]
Oshio, C [1 ]
机构：
[1] Keio Univ, Fac Sci & Technol, Inst Biomed Engn, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
PROCEEDINGS OF THE 20TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY, VOL 20, PTS 1-6: BIOMEDICAL ENGINEERING TOWARDS THE YEAR 2000 AND BEYOND | 1998年 / 20卷
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D O I：
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中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In microcirculation, RBC deformability is one of the most important factor. In this study, the effect of aldose reductase inhibitor (ARI) on RBC deformability in diabetic rats was investigated. Seven-week-old Wistar male rats were used as a diabetic model. We injected streptozotocin (STZ) (55mg/kg) intraperitoneally to make them diabetic. And then we administered ARI orally to the STZ rats. We classified them into STZ injected diabetic group (DM) and STZ and ARI treated diabetic group (ARI). Experiments were performed three weeks after STZ treatment. The RBC deformability was measured directly from the microscope images of mesentery. From this experiment, it was found that ARI didn't alter HbA1c, but improved the decreased RBC deformability in diabetes to the normal level.
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页码：3098 / 3099
页数：2
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