The role of P2X7 purinergic receptors in inflammatory and nociceptive changes accompanying cyclophosphamide-induced haemorrhagic cystitis in mice

被引：52

作者：

Martins, J. P.

Silva, R. B. M.

Coutinho-Silva, R. ^{[1
]}

Takiya, C. M. ^{[2
]}

Battastini, A. M. O. ^{[3
]}

Morrone, F. B. ^{[4
]}

Campos, M. M. ^{[4
,5
]}

机构：

[1] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, Rio de Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Rio de Janeiro, RJ, Brazil

[3] Univ Fed Rio Grande do Sul, Dept Bioquim, ICBS, Porto Alegre, RS, Brazil

[4] Pontificia Univ Catolica Rio de Janeiro, Inst Toxicol, BR-90619900 Porto Alegre, RS, Brazil

[5] Pontificia Univ Catolica Rio de Janeiro, Fac Odontol, BR-90619900 Porto Alegre, RS, Brazil

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 01期

关键词：

P2X7; receptor; haemorrhagic cystitis; cyclophosphamide; A-438079; genetic ablation; mice; P2X(7) RECEPTOR; EXTRACELLULAR ATP; PURINOCEPTOR EXPRESSION; QUANTITATIVE-ANALYSIS; BLADDER STIMULATION; URINARY-BLADDER; MODEL; PAIN; INTERLEUKIN-1-BETA; PHARMACOLOGY;

D O I：

10.1111/j.1476-5381.2011.01535.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND AND PURPOSE ATP is released in response to cellular damage, and P2X7 receptors have an essential role in the onset and maintenance of pathological changes. Haemorrhagic cystitis (HC) is a well-known adverse effect of therapy with cyclophosphamide used for the treatment of many solid tumours and autoimmune conditions. Here we have evaluated the role of P2X7 receptors in a model of HC induced by cyclophosphamide.

引用

页码：183 / 196

页数：14

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[1] Special Issue: Guide to Receptors and Channels, 5th Edition Abstracts [J].