Recent Advances in the Asymmetric Total Synthesis of Camptothecin

被引：4

作者：

Song, Liangliang ^{[1
]}

Lv, Zhenwei ^{[1
]}

Zhang, Kui ^{[1
]}

Wu, Yile ^{[2
]}

Van der Eycken, Erik V. ^{[3
,4
]}

Cai, Lingchao ^{[1
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat F, Nanjing 210037, Peoples R China

[2] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Zhejiang, Peoples R China

[3] Univ Leuven, Lab Organ & Amp Microwave Assisted Chem LOMAC, Dept Chem, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium

[4] Peoples Friendship Univ Russia, RUDN Univ, Miklukho Maklaya St 6, Moscow 117198, Russia

来源：

ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 11卷 / 11期

基金：

中国国家自然科学基金;

关键词：

total synthesis; asymmetric catalysis; camptothecin; alkaloids; natural product; CATALYTIC ENANTIOSELECTIVE SYNTHESIS; PLANT ANTITUMOR AGENTS; FORMAL TOTAL-SYNTHESIS; (20S)-CAMPTOTHECIN FAMILY; TOPOISOMERASE-I; (+)-CAMPTOTHECIN; CYCLIZATION; RESOLUTION; 20(S)-CAMPTOTHECIN; HYDROXYLATION;

D O I：

10.1002/ajoc.202200515

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

During the past decades, a variety of routes for the total synthesis of camptothecin have been reported. Considering only (S)-camptothecin and (S)-camptothecin analogues possessing the ability to inhibit DNA enzyme topoisomerase I, numerous advances have been achieved for the asymmetric total synthesis of camptothecin, providing concise and scalable approaches to (S)-camptothecin for the academic community and pharmaceutical industry. This review outlines recent advances in the asymmetric total synthesis of camptothecin, and is timely and highly desirable for the rapid development of this field. By constructing the chiral tertiary alcohol center, diverse attractive strategies have been developed for the total synthesis of (S)-camptothecin.

引用

页数：19