Pathogenicity and virulence of Burkholderia pseudomallei

被引:19
作者
Bzdyl, Nicole M. [1 ]
Moran, Clare L. [1 ]
Bendo, Justine [1 ]
Sarkar-Tyson, Mitali [1 ]
机构
[1] Univ Western Australia, Marshall Ctr Infect Dis Res & Training, Sch Biomed Sci, Perth, WA, Australia
关键词
Virulence; melioidosis; pathogenesis; Burkholderia pseudomallei; actin tails; multinucleated giant cells; VI SECRETION SYSTEM; ANTIGENIC POLYSACCHARIDE MOIETY; INTRACELLULAR LIFE-CYCLE; ACTIN-BASED MOTILITY; GIANT-CELL FORMATION; KATG-DPSA OPERON; CAPSULAR POLYSACCHARIDE; NITRIC-OXIDE; IN-VIVO; MOLECULAR CHARACTERIZATION;
D O I
10.1080/21505594.2022.2139063
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by either inhalation or inoculation can lead to severe disease. B. pseudomallei rapidly shifts from an environmental organism to an aggressive intracellular pathogen capable of rapidly spreading around the body. The expression of multiple virulence factors at every stage of intracellular infection allows for rapid progression of infection. Following invasion or phagocytosis, B. pseudomallei resists host-cell killing mechanisms in the phagosome, followed by escape using the type III secretion system. Several secreted virulence factors manipulate the host cell, while bacterial cells undergo a shift in energy metabolism allowing for overwhelming intracellular replication. Polymerisation of host cell actin into "actin tails" propels B. pseudomallei to the membranes of host cells where the type VI secretion system fuses host cells into multinucleated giant cells (MNGCs) to facilitate cell-to-cell dissemination. This review describes the various mechanisms used by B. pseudomallei to survive within cells.
引用
收藏
页码:1945 / 1965
页数:21
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