Novel blood-brain barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging

被引：10
|
作者：
Wang, Xiaolei [1 ,4 ,5 ]
Emoto, Miho [2 ]
Miyake, Yusuke [3 ,6 ]
Itto, Kaori [1 ]
Xu, Shu [1 ,4 ,5 ]
Fujii, Hirotada [3 ]
Hirata, Hiroshi
Arimoto, Hirokazu [1 ]
机构：
[1] Tohoku Univ, Grad Sch Life Sci, Dept Biomol Sci, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan
[2] Sapporo Med Univ, Dept Arts & Sci, Ctr Med Educ, Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan
[3] Hokkaido Univ, Grad Sch Informat Sci & Technol, Div Bioengn & Bioinformat, Kita Ku, North 14,West 9, Sapporo, Hokkaido 0600814, Japan
[4] Chinese Acad Med Sci, Inst Mat Med, 1 Xian Nong Tan St, Beijing 100050, Peoples R China
[5] Peking Union Med Coll, 1 Xian Nong Tan St, Beijing 100050, Peoples R China
[6] Kyoto Inst Technol, Grad Sch Sci & Technol, Sakyo Ku, Goshokaido Cho, Kyoto 6068585, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 20期
基金：
日本学术振兴会;
关键词：
Blood-brain barrier permeable; Spin probe; EPR brain imaging; Nitroxide; NICOTINIC ACETYLCHOLINE-RECEPTORS; CENTRAL-NERVOUS-SYSTEM; REDOX STATUS; MOUSE MODEL; ANALOGS; A-84543; NITROXIDES; PYRIDINE; LIGAND;
D O I：
10.1016/j.bmcl.2016.09.010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel blood-brain barrier (BBB)-permeable compound 10 was discovered, wherein the nitroxide moiety was linked to a nicotine acetylcholine receptor ligand. It was applied as a probe for electron paramagnetic resonance (EPR) imaging of the mouse brain. The results demonstrated that the newly synthesized compound 10 exhibited BBB permeability. These findings provide an essential discovery for in vivo EPR imaging. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4947 / 4949
页数：3
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