Systemic lupus erythematosus complicated with cerebral venous sinus thrombosis: A report of two cases

被引:15
作者
Lee, MK [1 ]
Kim, JH [1 ]
Kang, HR [1 ]
Rho, HJ [1 ]
Nam, EJ [1 ]
Kim, SW [1 ]
Kang, YM [1 ]
Lee, JM [1 ]
Kim, NS [1 ]
机构
[1] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu 702701, South Korea
关键词
systemic lupus erythematosus; sinus thrombosis; intracranial;
D O I
10.3346/jkms.2001.16.3.351
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A rare manifestation of systemic lupus erythematosus (SLE) is cerebral venous sinus thrombosis (CVST), in which early diagnosis and aggressive therapy are of prime importance for favorable outcome. The pathogenesis of CVST is largely unknown, but it is thought to be caused by cerebral vasculitis, antiphospholipid antibodies or other conditions associated with enhanced coagulability. We describe two cases of SLE with CVST which were not associated with antiphospholipid antibodies. Both cases were treated with immunosuppressants (intravenous methylprednisolone and cyclophosphamide pulse therapy) and anticoagulant drugs (heparin and subsequent maintenance therapy with warfarin). There was a marked improvement of neurologic symptoms with the disappearance of thrombus in a follow-up MRI. The possibility of CVST should be considered in any patients with SLE who show neuropsychiatric manifestations.
引用
收藏
页码:351 / 354
页数:4
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