Brain abscesses caused by Cladophialophora bantiana in a lung transplant patient: A case report and review of the literature

被引：3

作者：

Gschwend, Anthony ^{[1
]}

Degot, Tristan ^{[1
]}

Denis, Julie ^{[2
,3
]}

Sabou, Alina M. ^{[2
,3
]}

Jeung, Mi Young ^{[4
]}

Zapata, Emilie ^{[1
]}

Porzio, Michele ^{[1
]}

Renaud-Picard, Benjamin ^{[1
,5
]}

Herbrecht, Raoul ^{[6
]}

Kessler, Romain ^{[1
,5
]}

机构：

[1] Hop Univ Strasbourg, Federat Med Translat FMTS, Serv Pneumol, Nouvel Hop Civil, Strasbourg, France

[2] Hop Univ Strasbourg, Lab Parasitol & Mycol Med, Plateau Tech Microbiol, Strasbourg, France

[3] Univ Strasbourg, Inst Parasitol & Pathol Trop, Federat Med Translat FMTS, EA 7292, Strasbourg, France

[4] Hop Univ Strasbourg, Serv Radiol B, Nouvel Hop Civil, Strasbourg, France

[5] Univ Strasbourg, EA Stress Vasc & Tissulaire Transplant 7293, Strasbourg, France

[6] Hop Univ Strasbourg, Serv Hematol & dOncol, Hop Hautepierre, Strasbourg, France

来源：

TRANSPLANT INFECTIOUS DISEASE | 2017年 / 19卷 / 06期

关键词：

antifungal treatment; brain abscess; Cladophialophora bantiana; lung transplantation; survival; PHEOHYPHOMYCOSIS;

D O I：

10.1111/tid.12787

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cladophialophora bantiana brain abscesses are rare, but are frequently and quickly lethal in transplanted patients. We report the case of a 63-year-old man who had undergone lung transplantation for chronic obstructive pulmonary disease and presented with headaches and a neurological deficit. Magnetic resonance imaging revealed multiple brain abscesses. C.bantiana was identified by DNA sequencing performed directly on cerebral tissue obtained by surgical biopsy. After 6months of antifungal treatment, the brain abscesses were replaced by ischemic sequelae. The patient died suddenly 2months later from a pulmonary bacterial infection. This is the second reported case of C.bantiana brain abscesses in a lung transplant recipient, to our knowledge, who experienced a long survival period with medical antifungal treatment alone. We review the literature and discuss our treatment.

引用

页数：5

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